HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: I12R2 (Q99665)
Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
Gene: IL12RB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.53	0.80	0.657

Property	Details
Experiments	14559241
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 862
+	Mm
		193384 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		IL6RB_MOUSE (9-716): 1.04e-104: 346: 23.10
+	Mm
		435879 HCK_MOUSE (14-223): 4.94e-46: 161: 15.04		CSF3R_MOUSE (5-843): 2.27e-95: 319: 19.10
+	Hs
		434111 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ROBO1_HUMAN (8-785): 1.06e-56: 214: 9.94
+	Mm
		56907 FYN_MOUSE (35-223): 5.56e-48: 166: 13.90		PTPRF_MOUSE (3-750): 2.79e-54: 207: 11.37
+	Hs
		412016 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRD_HUMAN (3-705): 2.39e-54: 207: 11.48
+	Hs
		411959 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		PTPRF_HUMAN (3-564): 1.71e-51: 198: 13.01
+	Hs
		411565 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		PTPRF_HUMAN (3-564): 1.71e-51: 198: 13.01
+	Hs
		434019 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		ROBO2_HUMAN (30-779): 3.15e-40: 163: 10.94
+	Hs
		433804 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		SDK2_HUMAN (11-841): 5.96e-40: 162: 10.69
+	Hs
		147398 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		IL6RB_HUMAN (321-857): 1.25e-26: 118: 10.67
+	Hs
		442787 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		IL6RB_HUMAN (321-857): 1.25e-26: 118: 10.67
+	Hs
		147442 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CSF3R_HUMAN (363-861): 2.46e-20: 98.9: 10.52
+	Hs
		442875 HCK_HUMAN (14-223): 1.25e-47: 165: 15.85		CSF3R_HUMAN (363-861): 2.46e-20: 98.9: 10.52
+	Hs
		433961 LYN_HUMAN (14-223): 2.68e-46: 161: 15.70		CSF3R_HUMAN (363-861): 2.46e-20: 98.9: 10.52
+	Mm
		193379 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		LEPR_MOUSE (129-316): 9.36e-12: 71: 16.91
+	Mm
		817307 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		LEPR_MOUSE (129-316): 9.36e-12: 71: 16.91
+	Hs
		297881 FYN_HUMAN (35-223): 1.77e-47: 165: 13.90		NFASC_HUMAN (124-504): 1.12e-14: 80.7: 16.87
+	Hs
		147403 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		LEPR_HUMAN (210-316): 6.47e-11: 68.3: 20.00
+	Mm
		817309 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		LEPR_MOUSE (129-316): 9.36e-12: 71: 16.91
+	Mm
		817306 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		LEPR_MOUSE (129-316): 9.36e-12: 71: 16.91