HitPredict

Interactor 1: DVL1 (O14640)
Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)
Gene: DVL1

Interactor 2: SMAD2 (Q15796)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2)
Gene: SMAD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12650946
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription GO:0035556 - intracellular signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 695 Hs			1 467
+	Mm
		844423 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD2_MOUSE (1-467): 0: 675: 99.57
+	Hs
		150693 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		844410 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD1_MOUSE (1-467): 0: 566: 55.42
+	Hs
		150710 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		150947 DVL2_HUMAN (3-695): 1.59e-140: 430: 55.84		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Mm
		844412 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD4_MOUSE (11-456): 1.37e-150: 441: 31.46
+	Hs
		150701 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		876396 AFAD_HUMAN (246-658): 1.91e-82: 288: 20.83		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Mm
		192484 DVL1_MOUSE (1-695): 0: 559: 94.83		SMAD7_MOUSE (13-443): 5.17e-112: 338: 25.00
+	Hs
		150650 DVL1_HUMAN (1-695): 0: 550: 100.00		SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23
+	Hs
		1078635 NEB2_HUMAN (75-423): 2.81e-47: 181: 15.34		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1078579 RIMS1_HUMAN (8-675): 6.11e-45: 175: 14.18		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		1078596 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD2_HUMAN (1-467): 0: 675: 100.00
+	Hs
		950340 GRIP1_HUMAN (163-625): 8.94e-21: 99: 12.70		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		950226 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD3_HUMAN (1-467): 0: 617: 83.94
+	Hs
		1078732 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD1_HUMAN (1-467): 0: 565: 55.53
+	Hs
		1035517 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD4_HUMAN (11-456): 4.53e-151: 443: 31.58
+	Hs
		167376 PARD3_HUMAN (120-569): 9.22e-18: 90.3: 16.15		SMAD7_HUMAN (13-443): 2.55e-109: 331: 25.23