Protein: NHP2
H/ACA ribonucleoprotein complex subunit NHP2 (H/ACA snoRNP protein NHP2) (High mobility group-like nuclear protein 2)

Gene: NHP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 143
UniProt ID: P32495

Gene Ontology (top 5):
GO:0000454 - snoRNA guided rRNA pseudouridine synthesis
GO:0000493 - box H/ACA snoRNP assembly
GO:0005730 - nucleolus
GO:0005732 - sno(s)RNA-containing ribonucleoprotein complex
GO:0006364 - rRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738194

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

12

4

Small-scale

0.980

High

738284

NOP10
H/ACA ribonucleoprotein complex subunit NOP10

5

2

Small-scale

0.920

High

585232

FBRL
rRNA 2'-O-methyltransferase fibrillarin

4

2

Small-scale

0.886

High

738228

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

1

High-throughput

0.864

High

738255

ERB1
Ribosome biogenesis protein ERB1

3

7

High-throughput

0.839

High

632541

DBP3
ATP-dependent RNA helicase DBP3

2

4

High-throughput

0.789

High

738250

HAS1
ATP-dependent RNA helicase HAS1

2

15

High-throughput

0.759

High

700213

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

8

4

Small-scale

0.751

High

738239

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

8

1

Small-scale

0.748

High

666417

DBP2
ATP-dependent RNA helicase DBP2

1

4

High-throughput

0.698

High

738234

DBP6
ATP-dependent RNA helicase DBP6

1

7

High-throughput

0.698

High

627838

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

10

High-throughput

0.679

High

738230

PESC
Pescadillo homolog

1

2

High-throughput

0.665

High

677906

YCQ6
Uncharacterized protein YCR016W

3

1

High-throughput

0.650

High

738211

NOC2
Nucleolar complex protein 2

3

2

High-throughput

0.643

High

738219

UTP10
U3 small nucleolar RNA-associated protein 10

3

3

High-throughput

0.643

High

738260

UTP21
U3 small nucleolar RNA-associated protein 21

3

6

Small-scale

0.643

High

738269

NOP6
Nucleolar protein 6

3

0

High-throughput

0.638

High

738256

YM91
Putative methyltransferase YMR310C

4

1

High-throughput

0.623

High

149651

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.618

High

435847

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.618

High

637189

PWP1
Periodic tryptophan protein 1

1

13

High-throughput

0.618

High

682207

SPB4
ATP-dependent rRNA helicase SPB4

1

11

High-throughput

0.618

High

738202

DBP7
ATP-dependent RNA helicase DBP7

1

14

Small-scale

0.618

High

738206

ENP1
Essential nuclear protein 1

1

3

High-throughput

0.618

High

738253

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.618

High

738281

NOP56
Nucleolar protein 56

1

9

High-throughput

0.618

High

738282

NOP58
Nucleolar protein 58

1

9

High-throughput

0.618

High

738197

URB1
Nucleolar pre-ribosomal-associated protein 1

3

0

Small-scale

0.616

High

677320

KRR1
KRR1 small subunit processome component

2

4

High-throughput

0.601

High

738203

RPF2
Ribosome biogenesis protein RPF2

2

4

High-throughput

0.601

High

738232

YG5X
Putative methyltransferase YGR283C

2

1

High-throughput

0.601

High

738279

UTP23
rRNA-processing protein UTP23

2

2

Small-scale

0.595

High

569734

RL30
Large ribosomal subunit protein eL30

1

3

High-throughput

0.575

High

645334

XRN1
5'-3' exoribonuclease 1

2

2

High-throughput

0.571

High

738257

RRP5
rRNA biogenesis protein RRP5

2

2

High-throughput

0.571

High

433518

RL26A
Large ribosomal subunit protein uL24A

1

7

High-throughput

0.553

High

436352

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.553

High

584200

MS116
ATP-dependent RNA helicase MSS116, mitochondrial

1

15

High-throughput

0.553

High

738205

GBLP
Small ribosomal subunit protein RACK1

1

12

High-throughput

0.553

High

738224

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.553

High

738258

HRQ1
ATP-dependent helicase HRQ1

1

7

Small-scale

0.553

High

738273

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.553

High

738213

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.552

High

738201

EBP2
rRNA-processing protein EBP2

1

3

High-throughput

0.541

High

738231

PXR1
Protein PXR1

1

1

High-throughput

0.541

High

676896

SRO9
RNA-binding protein SRO9

2

6

High-throughput

0.537

High

735451

AAR2
A1 cistron-splicing factor AAR2

2

1

High-throughput

0.537

High

738200

SN114
Pre-mRNA-splicing factor SNU114

2

4

High-throughput

0.537

High

738212

RSMB
Small nuclear ribonucleoprotein-associated protein B

2

3

High-throughput

0.537

High

738280

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

2

High-throughput

0.537

High

738215

DSN1
Kinetochore-associated protein DSN1

2

3

High-throughput

0.533

High

383584

RS17A
Small ribosomal subunit protein eS17A

2

3

High-throughput

0.521

High

403409

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

2

Small-scale

0.521

High

738193

RSSA1
Small ribosomal subunit protein uS2A

2

2

High-throughput

0.521

High

738221

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.518

High

738218

KRI1
Protein KRI1

1

1

High-throughput

0.515

High

738251

HMO1
High mobility group protein 1

1

6

High-throughput

0.515

High

738191

BRR2
Pre-mRNA-splicing helicase BRR2

1

5

High-throughput

0.514

High

721775

XPO1
Exportin-1

1

4

High-throughput

0.489

High

738235

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

738245

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

6

High-throughput

0.489

High

738214

SHQ1
Protein SHQ1

1

0

Small-scale

0.480

High

441781

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

512323

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

674486

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

689333

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

738208

SSF1
Ribosome biogenesis protein SSF1

1

4

High-throughput

0.479

High

738216

RLP7
Ribosome biogenesis protein RLP7

1

8

High-throughput

0.479

High

738222

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

738233

PAP2
Poly(A) RNA polymerase protein 2

1

4

Small-scale

0.479

High

738240

NOP15
Ribosome biogenesis protein 15

1

5

High-throughput

0.479

High

738248

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.479

High

738261

MRD1
Multiple RNA-binding domain-containing protein 1

1

4

High-throughput

0.479

High

738266

NOC4
Nucleolar complex protein 4

1

7

High-throughput

0.479

High

738277

MAK21
Ribosome biogenesis protein MAK21

1

7

High-throughput

0.479

High

419654

H2A2
Histone H2A.2

1

5

High-throughput

0.470

High

738209

STM1
Suppressor protein STM1

1

2

High-throughput

0.470

High

738249

TMA23
Protein TMA23

1

0

High-throughput

0.458

High

738259

RSA3
Ribosome assembly protein 3

1

0

High-throughput

0.458

High

738271

NOP8
60S ribosome subunit biogenesis protein NOP8

1

0

High-throughput

0.458

High

738264

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.457

High

738244

SEN1
Helicase SEN1

1

3

Small-scale

0.445

High

364413

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.437

High

410001

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

454938

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

502918

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504102

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.437

High

512887

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514521

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

554570

RM02
Large ribosomal subunit protein bL27m

1

1

High-throughput

0.437

High

594254

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.437

High

644888

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.437

High

706517

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

708697

TF3B
Transcription factor IIIB 70 kDa subunit

1

5

High-throughput

0.437

High

726847

HS104
Heat shock protein 104

1

3

High-throughput

0.437

High

738192

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.437

High

738196

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

738198

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

738199

EAP1
Protein EAP1

1

2

High-throughput

0.437

High

738207

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

738210

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

738223

MOG1
Nuclear import protein MOG1

1

2

High-throughput

0.437

High

738229

EIF2A
Eukaryotic translation initiation factor 2A

1

3

High-throughput

0.437

High

738237

GIS2
Zinc finger protein GIS2

1

7

High-throughput

0.437

High

738241

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.437

High

738242

SAM50
Sorting assembly machinery 50 kDa subunit

1

3

High-throughput

0.437

High

738243

NUM1
Nuclear migration protein NUM1

1

4

High-throughput

0.437

High

738246

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

738254

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.437

High

738262

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

738263

PEX30
Peroxisomal membrane protein PEX30

1

1

Small-scale

0.437

High

738265

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

738267

RM35
Large ribosomal subunit protein mL38

1

1

High-throughput

0.437

High

738268

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

738272

SGO1
Shugoshin

1

3

High-throughput

0.437

High

738274

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.437

High

738275

AP3D
AP-3 complex subunit delta

1

3

High-throughput

0.437

High

427183

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.407

High

510309

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.407

High

526187

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.407

High

531655

RL4A
Large ribosomal subunit protein uL4A

1

6

High-throughput

0.407

High

676705

GBP2
Serine/arginine

1

2

High-throughput

0.407

High

684657

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.407

High

738195

PRP8
Pre-mRNA-splicing factor 8

1

1

High-throughput

0.407

High

738225

RL4B
Large ribosomal subunit protein uL4B

1

6

High-throughput

0.407

High

738226

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.407

High

738227

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

738278

SMT3
Ubiquitin-like protein SMT3

2

0

High-throughput

0.313

High

738252

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.279

Low

738236

ENG1
Glucan endo-1,3-beta-D-glucosidase 1

1

0

High-throughput

0.269

Low

738270

COQ10
Coenzyme Q-binding protein COQ10, mitochondrial

1

0

High-throughput

0.269

Low

738283

YD381
Uncharacterized mitochondrial outer membrane protein YDR381C-A

1

0

High-throughput

0.269

Low

417054

VDAC1
Non-selective voltage-gated ion channel 1

1

0

Small-scale

0.249

Low

448293

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

561438

TBP
TATA-box-binding protein

1

0

High-throughput

0.249

Low

709629

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

738204

RM17
Large ribosomal subunit protein mL46

1

0

High-throughput

0.249

Low

738217

RN49
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.249

Low

738238

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low

738247

RM13
Large ribosomal subunit protein mL50

1

0

High-throughput

0.249

Low

738220

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

Small-scale

0.232

Low

738276

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025