HitPredict

Interactor 1: DVL2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)
Gene: DVL2

Interactor 2: PI3R4 (Q99570)
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)
Gene: PIK3R4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	25825496, 36398662
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DEP~WD40
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 736 Hs			1 1358
+	Hs
		150982 DVL2_HUMAN (1-736): 0: 547: 100.00		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Rn
		92840 DLG4_RAT (108-707): 4.11e-75: 258: 15.53		CTRO_RAT (3-864): 5.71e-147: 494: 12.47
+	Mm
		823534 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		CTRO_MOUSE (10-864): 4.87e-138: 468: 12.34
+	Mm
		1131547 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		Q5SVI3_MOUSE (24-473): 1.19e-109: 358: 15.22
+	Hs
		1021591 DLG1_HUMAN (94-707): 5.4e-83: 284: 15.92		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Rn
		506740 DLG1_RAT (94-707): 2.78e-80: 277: 15.12		KCC2A_RAT (24-470): 3.62e-98: 324: 15.35
+	Mm
		659457 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		KCC2B_MOUSE (24-470): 6.44e-103: 340: 15.13
+	Mm
		1143346 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		KCC2D_MOUSE (24-470): 8.31e-101: 332: 14.91
+	Mm
		515234 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		KCC2A_MOUSE (24-470): 3.62e-98: 324: 15.35
+	Hs
		1271040 DLG3_HUMAN (80-706): 1.51e-73: 256: 14.93		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Rn
		506744 DLG3_RAT (80-706): 4.53e-72: 253: 15.10		KCC2A_RAT (24-470): 3.62e-98: 324: 15.35
+	Hs
		148925 MAGI3_HUMAN (223-577): 5.73e-16: 84.5: 11.78		CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77
+	Hs
		149079 INADL_HUMAN (243-345): 1.2e-12: 73.8: 26.85		CTRO_HUMAN (10-864): 4.4e-129: 442: 11.77
+	Hs
		1039101 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		KCC2D_HUMAN (24-470): 8.31e-101: 332: 14.91
+	Hs
		1200029 RIMS1_HUMAN (92-722): 9.64e-47: 181: 14.15		KCC2A_HUMAN (24-470): 2.2e-98: 325: 15.35
+	Hs
		1327341 NEB1_HUMAN (93-347): 2.94e-43: 171: 17.58		NUAK2_HUMAN (7-311): 1.51e-67: 242: 18.91
+	Mm
		1113263 DLG4_MOUSE (108-707): 2.57e-75: 259: 15.85		CDKL5_MOUSE (21-309): 1.54e-13: 77.9: 20.43
+	Mm
		936178 DLG3_MOUSE (80-706): 1.04e-71: 252: 15.33		CDKL5_MOUSE (21-309): 1.54e-13: 77.9: 20.43
+	Mm
		1113297 DLG2_MOUSE (93-707): 2.89e-70: 248: 12.83		CDKL5_MOUSE (21-309): 1.54e-13: 77.9: 20.43
+	Mm
		1113306 AFAD_MOUSE (256-702): 1.28e-45: 178: 19.48		CDKL5_MOUSE (21-309): 1.54e-13: 77.9: 20.43