Protein: NOP12
Nucleolar protein 12

Gene: NOP12
Organism: Saccharomyces cerevisiae S288C
Interactions: 171
UniProt ID: Q08208

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005730 - nucleolus
GO:0019843 - rRNA binding
GO:0030684 - preribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791119

NOP4
Nucleolar protein 4

6

19

Small-scale

0.951

High

1062340

NOP12
Nucleolar protein 12

3

15

High-throughput

0.834

High

518146

SSBP1
Single-stranded nucleic acid-binding protein

2

17

High-throughput

0.789

High

924859

NOP15
Ribosome biogenesis protein 15

2

19

High-throughput

0.754

High

1062351

YRA1
RNA annealing protein YRA1

2

18

Small-scale

0.754

High

793538

MAK5
ATP-dependent RNA helicase MAK5

6

20

High-throughput

0.730

High

814402

NOC2
Nucleolar complex protein 2

5

2

Small-scale

0.711

High

780331

EBP2
rRNA-processing protein EBP2

5

2

Small-scale

0.705

High

586038

CSK21
Casein kinase II subunit alpha

1

19

High-throughput

0.691

High

1053613

MRD1
Multiple RNA-binding domain-containing protein 1

1

15

Small-scale

0.691

High

1062353

RL7B
Large ribosomal subunit protein uL30B

1

12

High-throughput

0.691

High

637293

PWP1
Periodic tryptophan protein 1

4

20

High-throughput

0.691

High

1062352

MAK21
Ribosome biogenesis protein MAK21

4

9

High-throughput

0.691

High

782468

RPF2
Ribosome biogenesis protein RPF2

4

3

Small-scale

0.683

High

1062355

DBP10
ATP-dependent RNA helicase DBP10

4

20

High-throughput

0.680

High

850027

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

1

High-throughput

0.670

High

803952

CIC1
Proteasome-interacting protein CIC1

3

3

High-throughput

0.656

High

1043300

HAS1
ATP-dependent RNA helicase HAS1

3

20

High-throughput

0.656

High

1050188

RRP5
rRNA biogenesis protein RRP5

3

10

High-throughput

0.656

High

1062341

BRX1
Ribosome biogenesis protein BRX1

3

17

High-throughput

0.656

High

677248

SPB1
27S pre-rRNA

3

7

High-throughput

0.646

High

746683

DRS1
ATP-dependent RNA helicase DRS1

3

20

High-throughput

0.646

High

919023

PESC
Pescadillo homolog

3

1

High-throughput

0.640

High

1039644

NOG1
Nucleolar GTP-binding protein 1

3

7

Small-scale

0.640

High

632753

DBP4
ATP-dependent RNA helicase HCA4

2

20

High-throughput

0.621

High

722314

XPO1
Exportin-1

1

13

High-throughput

0.618

High

735279

KNS1
Dual specificity protein kinase KNS1

1

15

High-throughput

0.618

High

792731

YPK3
Serine/threonine-protein kinase YPK3

1

13

High-throughput

0.618

High

865558

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

8

High-throughput

0.618

High

1030261

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

9

High-throughput

0.618

High

1033867

KIN4
Serine/threonine-protein kinase KIN4

1

5

High-throughput

0.618

High

1040428

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

16

High-throughput

0.618

High

1042322

PKH3
Serine/threonine-protein kinase PKH3

1

10

High-throughput

0.618

High

1062350

RTK1
Probable serine/threonine-protein kinase RTK1

1

7

High-throughput

0.618

High

1062354

PKH2
Serine/threonine-protein kinase PKH2

1

15

High-throughput

0.618

High

410368

RL25
Large ribosomal subunit protein uL23

1

6

High-throughput

0.618

High

432717

RL7A
Large ribosomal subunit protein uL30A

1

12

High-throughput

0.618

High

435401

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

917494

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

5

High-throughput

0.611

High

657005

BUR1
Serine/threonine-protein kinase BUR1

1

13

High-throughput

0.595

High

1054256

FKBP4
FK506-binding protein 4

2

6

High-throughput

0.594

High

780716

RRP14
Ribosomal RNA-processing protein 14

2

1

Small-scale

0.586

High

682406

SPB4
ATP-dependent rRNA helicase SPB4

2

20

High-throughput

0.584

High

830196

NOP2
25S rRNA

2

5

Small-scale

0.584

High

1062349

NOP53
Ribosome biogenesis protein NOP53

2

5

High-throughput

0.584

High

602662

PHO85
Cyclin-dependent protein kinase PHO85

1

7

High-throughput

0.579

High

864379

SMC3
Structural maintenance of chromosomes protein 3

2

1

High-throughput

0.567

High

798332

ENP1
Essential nuclear protein 1

2

0

High-throughput

0.559

High

1061405

BUD20
Bud site selection protein 20

2

1

High-throughput

0.558

High

434451

RL15A
Large ribosomal subunit protein eL15A

1

3

High-throughput

0.536

High

885101

RL4B
Large ribosomal subunit protein uL4B

1

8

High-throughput

0.536

High

1054900

ESF1
Pre-rRNA-processing protein ESF1

1

1

High-throughput

0.536

High

1059253

TSR1
Ribosome biogenesis protein TSR1

1

1

High-throughput

0.536

High

751500

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

3

High-throughput

0.533

High

826891

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

864195

ALB1
Ribosome biogenesis protein ALB1

2

1

High-throughput

0.533

High

779167

DHR2
Probable ATP-dependent RNA helicase DHR2

1

7

High-throughput

0.515

High

1059612

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

1062356

RRP36
rRNA biogenesis protein RRP36

1

0

Small-scale

0.513

High

864044

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.493

High

668442

PTP1
Tyrosine-protein phosphatase 1

1

2

High-throughput

0.489

High

697399

MIG1
Regulatory protein MIG1

1

7

High-throughput

0.489

High

712764

PTP2
Tyrosine-protein phosphatase 2

1

2

High-throughput

0.489

High

751239

DOM34
Protein DOM34

1

1

High-throughput

0.489

High

923138

BRE5
UBP3-associated protein BRE5

1

13

High-throughput

0.489

High

1030591

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.489

High

154234

RL36B
Large ribosomal subunit protein eL36B

1

6

Small-scale

0.481

High

434200

RL36A
Large ribosomal subunit protein eL36A

1

6

Small-scale

0.481

High

149985

RS9A
Small ribosomal subunit protein uS4A

1

6

High-throughput

0.479

High

433879

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

436204

RS13
Small ribosomal subunit protein uS15

1

5

High-throughput

0.479

High

442140

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

455294

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

512687

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

514865

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

534153

MAK16
Protein MAK16

1

2

High-throughput

0.479

High

633200

MAK11
Protein MAK11

1

19

Small-scale

0.479

High

671188

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

673595

NLE1
Ribosome assembly protein 4

1

17

High-throughput

0.479

High

674868

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.479

High

677591

KRR1
KRR1 small subunit processome component

1

3

High-throughput

0.479

High

689697

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

712681

RL8B
Large ribosomal subunit protein eL8B

1

6

High-throughput

0.479

High

750158

MRT4
Ribosome assembly factor MRT4

1

4

High-throughput

0.479

High

763129

RRP1
Ribosomal RNA-processing protein 1

1

8

High-throughput

0.479

High

778565

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.479

High

795852

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

804674

SSF1
Ribosome biogenesis protein SSF1

1

4

High-throughput

0.479

High

805103

RPF1
Ribosome production factor 1

1

3

High-throughput

0.479

High

807162

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

6

High-throughput

0.479

High

815257

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

13

Small-scale

0.479

High

816805

NOP16
Nucleolar protein 16

1

1

High-throughput

0.479

High

816919

NUG1
Nuclear GTP-binding protein NUG1

1

7

High-throughput

0.479

High

818285

NSA2
Ribosome biogenesis protein NSA2

1

4

High-throughput

0.479

High

827625

RLP7
Ribosome biogenesis protein RLP7

1

12

High-throughput

0.479

High

844641

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

864534

MTR4
ATP-dependent RNA helicase DOB1

1

20

Small-scale

0.479

High

917571

NSA1
Ribosome biogenesis protein NSA1

1

1

High-throughput

0.479

High

923214

NOG2
Nucleolar GTP-binding protein 2

1

7

High-throughput

0.479

High

924198

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.479

High

925450

RCM1
25S rRNA

1

5

High-throughput

0.479

High

1033600

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

1038764

XRN2
5'-3' exoribonuclease 2

1

7

High-throughput

0.479

High

1042252

TOM1
E3 ubiquitin-protein ligase TOM1

1

13

High-throughput

0.479

High

1044229

ARX1
Probable metalloprotease ARX1

1

4

High-throughput

0.479

High

1044908

RRP17
Ribosomal RNA-processing protein 17

1

1

High-throughput

0.479

High

1046063

DHR1
Probable ATP-dependent RNA helicase DHR1

1

11

High-throughput

0.479

High

1046809

UTP14
U3 small nucleolar RNA-associated protein 14

1

2

High-throughput

0.479

High

1047293

ERB1
Ribosome biogenesis protein ERB1

1

12

High-throughput

0.479

High

1054369

JIP5
WD repeat-containing protein JIP5

1

14

High-throughput

0.479

High

1055475

RRP15
Ribosomal RNA-processing protein 15

1

1

High-throughput

0.479

High

1055501

NOC4
Nucleolar complex protein 4

1

9

High-throughput

0.479

High

1060739

NOC3
Nucleolar complex-associated protein 3

1

6

High-throughput

0.479

High

1060825

RLP24
Ribosome biogenesis protein RLP24

1

3

High-throughput

0.479

High

1062342

REXO4
RNA exonuclease 4

1

4

High-throughput

0.479

High

1062345

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

1062346

RRS1
Regulator of ribosome biosynthesis

1

4

High-throughput

0.479

High

1062347

NIP7
60S ribosome subunit biogenesis protein NIP7

1

2

High-throughput

0.479

High

1062348

YTM1
Ribosome biogenesis protein YTM1

1

18

High-throughput

0.479

High

1062357

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

924649

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1062358

EFG1P
rRNA-processing protein EFG1

1

0

High-throughput

0.458

High

1025194

SEN1
Helicase SEN1

1

14

Small-scale

0.445

High

825915

RL34B
Large ribosomal subunit protein eL34B

1

4

Small-scale

0.439

High

1018164

RL34A
Large ribosomal subunit protein eL34A

1

4

Small-scale

0.439

High

383924

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

436537

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

7

High-throughput

0.437

High

503274

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

504446

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.437

High

511305

RL20B
Large ribosomal subunit protein eL20B

1

2

High-throughput

0.437

High

513254

RS8A
Small ribosomal subunit protein eS8A

1

6

High-throughput

0.437

High

594605

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

708373

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

710018

BMH1
Protein BMH1

1

3

High-throughput

0.437

High

735200

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

747611

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

753621

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

785987

LONM
Lon protease homolog, mitochondrial

1

6

High-throughput

0.437

High

792281

GBLP
Small ribosomal subunit protein RACK1

1

15

High-throughput

0.437

High

802420

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.437

High

812718

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

826096

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.437

High

874564

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

897517

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.437

High

917698

LSG1
Large subunit GTPase 1

1

7

High-throughput

0.437

High

918478

EIF2A
Eukaryotic translation initiation factor 2A

1

4

High-throughput

0.437

High

932240

ORC1
Origin recognition complex subunit 1

1

5

High-throughput

0.437

High

1046318

VMS1
tRNA endonuclease VMS1

1

1

High-throughput

0.437

High

1046947

POB3
FACT complex subunit POB3

1

4

High-throughput

0.437

High

1053990

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

1059373

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

1062343

SGO1
Shugoshin

1

1

High-throughput

0.437

High

546531

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.407

High

819972

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.407

High

558882

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.305

High

449431

SPT2
Protein SPT2

1

0

High-throughput

0.279

Low

644671

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.279

Low

744807

ALK2
Serine/threonine-protein kinase Haspin homolog ALK2

1

0

High-throughput

0.279

Low

924032

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

1045067

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.279

Low

1055152

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.279

Low

1062344

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

665211

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.269

Low

797665

GDT1
Divalent cation/proton antiporter GDT1

1

0

High-throughput

0.269

Low

863345

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.269

Low

448340

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.249

Low

752818

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

780065

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

806667

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.249

Low

1043927

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025