HitPredict

Interactor 1: IRS4 (O14654)
Insulin receptor substrate 4 (IRS-4) (160 kDa phosphotyrosine protein) (py160) (Phosphoprotein of 160 kDa) (pp160)
Gene: IRS4

Interactor 2: PK3CA (P42336)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide 3-kinase alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: PIK3CA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	11912194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008286 - insulin receptor signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1257 Hs			1 1068
+	Hs
		151731 IRS4_HUMAN (1-1257): 0: 1632: 100.00		PK3CB_HUMAN (1-1064): 0: 1050: 39.52
+	Hs
		787336 IRS2_HUMAN (685-1085): 1.92e-18: 93.7: 21.82		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Hs
		724516 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		PK3CA_HUMAN (1-1068): 0: 1325: 100.00
+	Mm
		724577 IRS1_MOUSE (685-1099): 2.43e-15: 83.7: 18.51		PK3CA_MOUSE (1-1068): 0: 1317: 98.69
+	Dm
		954625 IRS1_DROME (83-354): 1.31e-71: 261: 30.00		P91634_DROME (7-1065): 0: 962: 34.40
+	Hs
		724517 IRS1_HUMAN (685-1104): 4.18e-16: 86.4: 19.17		PK3CB_HUMAN (1-1064): 0: 1050: 39.52
+	Rn
		88599 IRS1_RAT (685-1099): 3.05e-15: 83.3: 19.47		D3ZFJ0_RAT (1-1062): 0: 927: 32.35