HitPredict

Interactor 1: KMT2D (O14686)
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)
Gene: KMT2D

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.983

Property	Details
Experiments	31076518, 24981860, 33961781, 23508102, 15960974, 16603732, 27563068, 29785026, 30107592, 30604749, 36893259, 17925232, 24491801, 24081332, 17500065, 17178841
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding GO:0043627 - response to estrogen and 1 others more... GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 5537 Hs			1 538
+	Hs
		152663 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5B_HUMAN (2-225): 9.91e-62: 207: 16.88
+	Hs
		152678 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		152622 KMT2D_HUMAN (1-5537): 0: 1986: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Dm
		1129085 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		RBBP5_DROME (1-494): 3.54e-103: 320: 65.79
+	Hs
		203735 SUV91_HUMAN (5165-5536): 8.73e-94: 313: 18.38		DAW1_HUMAN (54-395): 7.21e-75: 244: 15.12
+	Sc
		755771 SET1_YEAST (5160-5537): 1.76e-83: 303: 27.25		SWD1_YEAST (1-356): 1.48e-77: 252: 30.08
+	Hs
		975258 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		1070808 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Sp
		194056 SET1_SCHPO (5320-5537): 5.36e-66: 247: 34.30		SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68
+	Hs
		1281314 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		903444 EHMT2_HUMAN (4886-5533): 3.48e-114: 398: 17.77		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		1078845 ITSN1_HUMAN (3410-4271): 7.27e-97: 353: 13.54		BRWD3_HUMAN (228-450): 4.8e-15: 80.8: 12.86
+	Hs
		1080207 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		1080166 EZH2_HUMAN (5194-5519): 5.62e-91: 317: 18.91		PHIP_HUMAN (227-374): 6.69e-15: 80.4: 13.91
+	At
		1319861 ATX1_ARATH (5318-5537): 4.41e-68: 255: 33.20		WDR5A_ARATH (182-434): 2.41e-37: 142: 16.93
+	Dm
		1129076 SET1_DROME (5244-5537): 1.28e-75: 284: 28.49		WDS_DROME (250-438): 1.02e-21: 98.5: 10.82
+	Hs
		975304 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		975303 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		903149 KMT2A_HUMAN (218-352): 5.26e-30: 135: 26.24		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		903604 KMT2B_HUMAN (79-219): 7.24e-25: 117: 24.31		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41