HitPredict

Interactor 1: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Interactor 2: NDC80 (O14777)
Kinetochore protein NDC80 homolog (Highly expressed in cancer protein) (Kinetochore protein Hec1) (HsHec1) (Kinetochore-associated protein 2) (Retinoblastoma-associated protein HEC)
Gene: NDC80

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 25416956, 20360068, 14602875
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, tandem affinity purification
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF5595~Ndc80_HEC, Ndc80_HEC~Ndc80_HEC
Common GO terms GO:0000070 - mitotic sister chromatid segregation
GO:0000132 - establishment of mitotic spindle orientation
GO:0000278 - mitotic cell cycle
GO:0000775 - chromosome, centromeric region
GO:0000776 - kinetochore
and 24 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 642
Hs

1 642
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+ Sc
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+ Mm

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Last updated: 15 Jul 2024