HitPredict

Interactor 1: NRP1 (O14786)
Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304)
Gene: NRP1

Interactor 2: GNAI2 (P04899)
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34709727
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0046872 - metal ion binding GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 923 Hs			1 355
+	Hs
		155328 NRP1_HUMAN (1-923): 0: 1068: 100.00		GNAI1_HUMAN (1-355): 8.33e-178: 498: 87.89
+	Hs
		155249 NRP1_HUMAN (1-923): 0: 1068: 100.00		GNAI3_HUMAN (1-355): 1.01e-174: 490: 85.92
+	Hs
		155304 NRP1_HUMAN (1-923): 0: 1068: 100.00		GNAQ_HUMAN (1-354): 8.04e-165: 466: 50.42
+	Hs
		155234 NRP1_HUMAN (1-923): 0: 1068: 100.00		GNA14_HUMAN (3-354): 2.08e-158: 449: 49.86
+	Hs
		155327 NRP1_HUMAN (1-923): 0: 1068: 100.00		GNAS2_HUMAN (1-355): 1.94e-147: 423: 38.83