Protein: MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19 protein) (WW domain-containing protein 3) (WWP3)

Gene: MAGI1
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q96QZ7

Gene Ontology (top 5):
GO:0001886 - endothelial cell morphogenesis
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1401146

RPGF2
Rap guanine nucleotide exchange factor 2

3

9

Small-scale

0.830

High

319240

FCSD2
F-BAR and double SH3 domains protein 2

2

11

Small-scale

0.825

High

1401128

ZO2
Tight junction protein 2

2

19

High-throughput

0.789

High

246108

KIF1B
Kinesin-like protein KIF1B

2

20

Small-scale

0.770

High

936419

AFAD
Afadin

2

20

High-throughput

0.754

High

1279517

ARHG8
Neuroepithelial cell-transforming gene 1 protein

8

18

Small-scale

0.741

High

1353249

PARD3
Partitioning defective 3 homolog

2

20

High-throughput

0.737

High

1401101

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

2

18

Small-scale

0.712

High

1401104

RSLBB
Ras-like protein family member 11B

2

2

High-throughput

0.700

High

988627

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.698

High

966774

1433G
14-3-3 protein gamma

4

20

High-throughput

0.697

High

1049691

1433F
14-3-3 protein eta

4

20

High-throughput

0.697

High

764977

CTNB1
Catenin beta-1

4

20

Small-scale

0.695

High

318935

DEND
Dendrin

1

1

Small-scale

0.680

High

1152030

PTN14
Tyrosine-protein phosphatase non-receptor type 14

3

20

High-throughput

0.667

High

1401110

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

2

2

Small-scale

0.629

High

730169

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.628

High

208722

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

12

High-throughput

0.618

High

245260

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

18

High-throughput

0.618

High

269601

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

20

High-throughput

0.618

High

374148

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375854

RASK
GTPase KRas

1

20

High-throughput

0.618

High

955496

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962401

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

978236

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1004169

CXAR
Coxsackievirus and adenovirus receptor

1

20

High-throughput

0.618

High

1092479

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

10

High-throughput

0.618

High

1216083

SPD2A
SH3 and PX domain-containing protein 2A

1

10

High-throughput

0.618

High

1255150

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1401113

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

1401115

KI13B
Kinesin-like protein KIF13B

1

20

High-throughput

0.618

High

1401123

SH3B4
SH3 domain-binding protein 4

1

1

High-throughput

0.618

High

1401124

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

20

High-throughput

0.618

High

1401144

STA13
StAR-related lipid transfer protein 13

1

20

High-throughput

0.618

High

181015

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

3

High-throughput

0.609

High

157751

CTRO
Citron Rho-interacting kinase

2

20

High-throughput

0.601

High

155251

AGRB1
Adhesion G protein-coupled receptor B1

2

18

Small-scale

0.594

High

349210

LATS1
Serine/threonine-protein kinase LATS1

2

20

High-throughput

0.584

High

556294

CADH1
Cadherin-1

2

8

Small-scale

0.584

High

1325437

SYNPO
Synaptopodin

1

10

Small-scale

0.578

High

1288689

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

19

High-throughput

0.575

High

1323648

DOCK4
Dedicator of cytokinesis protein 4

1

3

High-throughput

0.575

High

1325307

PALS1
Protein PALS1

1

20

High-throughput

0.575

High

1341088

INADL
InaD-like protein

1

20

High-throughput

0.575

High

1353173

RPGF6
Rap guanine nucleotide exchange factor 6

1

9

High-throughput

0.575

High

1353753

SHRM3
Protein Shroom3

1

9

High-throughput

0.575

High

1399986

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

16

High-throughput

0.575

High

1401112

P63
Tumor protein 63

1

6

High-throughput

0.575

High

1401126

TUTLA
Protein turtle homolog A

1

20

High-throughput

0.575

High

1148381

KS6A1
Ribosomal protein S6 kinase alpha-1

2

12

Small-scale

0.563

High

224779

ACTN4
Alpha-actinin-4

1

16

Small-scale

0.561

High

1085870

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

20

Small-scale

0.561

High

1352629

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

High-throughput

0.553

High

1401139

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

14

High-throughput

0.553

High

1381229

WBP2
WW domain-binding protein 2

2

3

Small-scale

0.553

High

617337

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

5

Small-scale

0.552

High

1401131

ASIC3
Acid-sensing ion channel 3

1

5

Small-scale

0.552

High

1401134

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.546

High

879747

MAPK2
MAP kinase-activated protein kinase 2

1

11

High-throughput

0.536

High

1110930

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.536

High

1401125

PCD10
Protocadherin-10

1

4

High-throughput

0.536

High

106507

APRIO
Alternative prion protein

2

5

High-throughput

0.533

High

928324

ATN1
Atrophin-1

1

11

Small-scale

0.527

High

1022640

LRP2
Low-density lipoprotein receptor-related protein 2

1

9

Small-scale

0.527

High

1381938

CK052
Uncharacterized protein C11orf52

2

6

High-throughput

0.521

High

730842

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

1271303

5MP2
eIF5-mimic protein 2

1

2

High-throughput

0.515

High

472228

ADRB1
Beta-1 adrenergic receptor

1

20

Small-scale

0.501

High

762206

CRFR1
Corticotropin-releasing factor receptor 1

1

20

Small-scale

0.501

High

1372007

LPP
Lipoma-preferred partner

1

7

Small-scale

0.501

High

1401120

CLTR2
Cysteinyl leukotriene receptor 2

1

20

High-throughput

0.501

High

1401121

IGSF5
Immunoglobulin superfamily member 5

1

5

Small-scale

0.481

High

138278

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

9

High-throughput

0.479

High

176866

DCLK1
Serine/threonine-protein kinase DCLK1

1

16

High-throughput

0.479

High

230561

KIF1C
Kinesin-like protein KIF1C

1

20

High-throughput

0.479

High

252142

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

299340

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

339099

NADK
NAD kinase

1

1

High-throughput

0.479

High

487652

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

637941

NF1
Neurofibromin

1

20

High-throughput

0.479

High

643034

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

20

High-throughput

0.479

High

657660

GCSP
Glycine dehydrogenase

1

2

High-throughput

0.479

High

719256

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.479

High

719362

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.479

High

744465

SSR3
Somatostatin receptor type 3

1

20

Small-scale

0.479

High

764413

CTNA1
Catenin alpha-1

1

6

High-throughput

0.479

High

862948

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

Small-scale

0.479

High

896616

VASP
Vasodilator-stimulated phosphoprotein

1

16

High-throughput

0.479

High

941043

HDAC4
Histone deacetylase 4

1

10

High-throughput

0.479

High

1008049

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

20

Small-scale

0.479

High

1025585

CDK16
Cyclin-dependent kinase 16

1

5

High-throughput

0.479

High

1041235

CAV1
Caveolin-1

1

5

High-throughput

0.479

High

1108061

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1129972

MELK
Maternal embryonic leucine zipper kinase

1

8

High-throughput

0.479

High

1134035

ZN638
Zinc finger protein 638

1

6

High-throughput

0.479

High

1159809

OCLN
Occludin

1

5

High-throughput

0.479

High

1197065

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1216017

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

7

High-throughput

0.479

High

1219611

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

1234914

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.479

High

1245705

LARP1
La-related protein 1

1

7

High-throughput

0.479

High

1257034

SYDE1
Rho GTPase-activating protein SYDE1

1

20

High-throughput

0.479

High

1286532

PHLB2
Pleckstrin homology-like domain family B member 2

1

17

High-throughput

0.479

High

1309236

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.479

High

1322631

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

1338099

NAV1
Neuron navigator 1

1

7

High-throughput

0.479

High

1352601

DEN1A
DENN domain-containing protein 1A

1

8

High-throughput

0.479

High

1356757

HDAC7
Histone deacetylase 7

1

10

High-throughput

0.479

High

1360391

SRS12
Serine/arginine-rich splicing factor 12

1

8

High-throughput

0.479

High

1401102

TESK2
Dual specificity testis-specific protein kinase 2

1

5

High-throughput

0.479

High

1401109

RTKN
Rhotekin

1

1

High-throughput

0.479

High

1401118

LATS2
Serine/threonine-protein kinase LATS2

1

20

High-throughput

0.479

High

1401119

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

4

High-throughput

0.479

High

1401127

CING
Cingulin

1

5

High-throughput

0.479

High

1401129

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1401130

LIMA1
LIM domain and actin-binding protein 1

1

5

High-throughput

0.479

High

1401132

XPO7
Exportin-7

1

5

High-throughput

0.479

High

1401133

NGAP
Ras GTPase-activating protein nGAP

1

20

High-throughput

0.479

High

1401135

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

6

High-throughput

0.479

High

1401136

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

1401137

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

1401138

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

1401140

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.479

High

1401143

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1401147

KCTD3
BTB/POZ domain-containing protein KCTD3

1

20

High-throughput

0.479

High

376895

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

1031510

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.458

High

1400855

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.458

High

1401105

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

372901

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.445

High

530246

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

540074

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.445

High

555742

ACTN1
Alpha-actinin-1

1

16

High-throughput

0.445

High

668697

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.445

High

675118

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.445

High

691353

1433T
14-3-3 protein theta

1

20

High-throughput

0.445

High

1062182

PCDH1
Protocadherin-1

1

4

High-throughput

0.445

High

1118763

KLF5
Krueppel-like factor 5

1

5

High-throughput

0.445

High

1231865

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

9

High-throughput

0.445

High

1232980

OTU7B
OTU domain-containing protein 7B

1

8

High-throughput

0.445

High

1258552

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

5

High-throughput

0.445

High

1314099

AMOL1
Angiomotin-like protein 1

1

20

High-throughput

0.445

High

1363677

TCPW
T-complex protein 1 subunit zeta-2

1

4

High-throughput

0.445

High

1364974

TSC1
Hamartin

1

20

High-throughput

0.445

High

1401103

PKP4
Plakophilin-4

1

20

High-throughput

0.445

High

1401116

ANLN
Anillin

1

4

High-throughput

0.445

High

1401117

TULP4
Tubby-related protein 4

1

6

High-throughput

0.445

High

1401142

AMOL2
Angiomotin-like protein 2

1

20

High-throughput

0.445

High

281396

GGYF1
GRB10-interacting GYF protein 1

1

8

High-throughput

0.437

High

1065751

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

14

High-throughput

0.437

High

1187129

TBC25
TBC1 domain family member 25

1

5

High-throughput

0.437

High

1229898

AN34A
Ankyrin repeat domain-containing protein 34A

1

20

High-throughput

0.437

High

1251413

GGYF2
GRB10-interacting GYF protein 2

1

18

High-throughput

0.437

High

1277705

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.437

High

1349469

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

1357409

DEP1B
DEP domain-containing protein 1B

1

14

High-throughput

0.437

High

1390399

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.437

High

1401106

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

1401107

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.437

High

1108385

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.426

High

1401111

TTYH3
Protein tweety homolog 3

1

0

High-throughput

0.426

High

1401114

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.426

High

876496

K2C6C
Keratin, type II cytoskeletal 6C

1

8

High-throughput

0.407

High

1127824

KRT81
Keratin, type II cuticular Hb1

1

8

High-throughput

0.407

High

1226232

CP135
Centrosomal protein of 135 kDa

1

8

High-throughput

0.407

High

1250762

MPRIP
Myosin phosphatase Rho-interacting protein

1

18

High-throughput

0.407

High

1395053

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.407

High

1401108

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.407

High

1401141

PKHA6
Pleckstrin homology domain-containing family A member 6

1

20

High-throughput

0.407

High

1391351

WBP1
WW domain-binding protein 1

1

1

Small-scale

0.373

High

1394696

CYYR1
Cysteine and tyrosine-rich protein 1

3

0

High-throughput

0.347

High

353512

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1401122

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

333833

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.232

Low

1307687

SPP2C
Signal peptide peptidase-like 2C

1

0

High-throughput

0.232

Low

1401145

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025