HitPredict

Interactor 1: SH21B (O14796)
SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)
Gene: SH2D1B

Interactor 2: SH21A (O60880)
SH2 domain-containing protein 1A (Duncan disease SH2-protein) (Signaling lymphocytic activation molecule-associated protein) (SLAM-associated protein) (T-cell signal transduction molecule SAP)
Gene: SH2D1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	16920955
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~SH2
Common GO terms	GO:0002250 - adaptive immune response GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 132 Hs			1 128
+	Mm
		435883 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		HCK_MOUSE (1-127): 9.56e-42: 145: 19.55
+	Hs
		176332 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72
+	Mm
		639445 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		LYN_MOUSE (1-125): 1.07e-39: 140: 19.85
+	Hs
		69199 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		A9UF07_HUMAN (1-127): 2.1e-39: 141: 26.72
+	Hs
		176351 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		LYN_HUMAN (1-125): 1.04e-39: 140: 19.85
+	Hs
		337307 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		ABL1_HUMAN (1-127): 4.39e-40: 143: 26.72
+	Hs
		155829 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SRC_HUMAN (1-127): 8.71e-39: 138: 20.90
+	Hs
		176483 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00
+	Mm
		763392 SH21C_MOUSE (1-132): 1.09e-41: 136: 65.91		FYN_MOUSE (1-125): 4.62e-37: 133: 18.52
+	Dm
		1360389 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		SRC42_DROME (1-123): 2.97e-38: 136: 25.81
+	Hs
		155850 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		SHIP1_HUMAN (4-103): 1.66e-37: 136: 43.00
+	Mm
		536205 FGR_MOUSE (3-124): 4.13e-35: 128: 24.22		FGR_MOUSE (1-126): 1.98e-39: 139: 22.56
+	Hs
		155835 SH21B_HUMAN (1-132): 1.12e-39: 131: 100.00		BLK_HUMAN (1-125): 7.14e-38: 135: 18.46
+	Hs
		176424 SHIP2_HUMAN (5-102): 1.32e-36: 133: 42.86		GRB2_HUMAN (1-123): 1.97e-35: 122: 19.69
+	Hs
		243121 FYN_HUMAN (3-125): 5.83e-35: 128: 22.48		SH21A_HUMAN (1-128): 3.11e-38: 127: 100.00
+	Mm
		763393 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		GRB2_MOUSE (1-123): 1.02e-35: 123: 19.69
+	Mm
		292397 FYN_MOUSE (3-125): 5.55e-35: 128: 22.48		SH21A_MOUSE (1-128): 3.55e-35: 119: 85.94
+	Dm
		1360391 SRC42_DROME (3-131): 3.55e-36: 131: 26.52		Q9VGK8_DROME (1-107): 4.07e-24: 97.8: 26.17
+	Mm
		536207 FGR_MOUSE (3-124): 4.13e-35: 128: 24.22		KSYK_MOUSE (5-120): 2.79e-15: 72.8: 24.79