HitPredict

Interactor 1: KLF11 (O14901)
Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)
Gene: KLF11

Interactor 2: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	22318730
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 512 Hs			1 191
+	Hs
		157896 KLF11_HUMAN (1-512): 3.64e-168: 487: 100.00		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		157891 KLF11_HUMAN (1-512): 3.64e-168: 487: 100.00		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		157850 KLF11_HUMAN (1-512): 3.64e-168: 487: 100.00		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		728565 ZNF93_HUMAN (52-481): 3.63e-127: 385: 12.74		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027081 ZN534_HUMAN (103-481): 8.66e-107: 334: 13.01		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027087 ZN571_HUMAN (53-448): 2.08e-107: 334: 11.71		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027217 ZN184_HUMAN (103-478): 6.99e-106: 334: 15.48		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027150 ZN480_HUMAN (62-420): 9.25e-103: 320: 7.90		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		988824 ZN33A_HUMAN (103-451): 1.65e-92: 300: 13.07		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027000 ZN846_HUMAN (176-510): 3.56e-86: 277: 16.81		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		800402 ZN568_HUMAN (56-354): 2.97e-71: 240: 7.81		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		316135 ZN184_HUMAN (103-478): 6.99e-106: 334: 15.48		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		1027027 ZN568_HUMAN (56-354): 2.97e-71: 240: 7.81		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		1027128 ZN565_HUMAN (334-504): 1.08e-69: 233: 23.67		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		549158 ZN250_HUMAN (53-349): 2.12e-68: 231: 9.00		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		240839 Z354A_HUMAN (242-510): 8.78e-61: 211: 15.46		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		316021 ZN33B_HUMAN (103-455): 9.56e-94: 303: 14.29		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		316020 ZN33A_HUMAN (103-451): 1.65e-92: 300: 13.07		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		316039 ZKSC8_HUMAN (62-480): 9.63e-74: 245: 17.05		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		315965 ZNF7_HUMAN (124-478): 4.54e-63: 219: 14.58		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18