Protein: HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)

Gene: HEY1
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q9Y5J3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458602

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

8

18

Small-scale

0.965

High

1126810

HES1
Transcription factor HES-1

5

18

Small-scale

0.918

High

1406455

PITX2
Pituitary homeobox 2

2

1

High-throughput

0.783

High

1108879

OLIG2
Oligodendrocyte transcription factor 2

1

12

High-throughput

0.698

High

1491691

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

16

Small-scale

0.647

High

693383

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

7

Small-scale

0.621

High

581747

MYOD1
Myoblast determination protein 1

1

13

Small-scale

0.618

High

288053

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

1

Small-scale

0.611

High

504775

FBSP1
F-box/SPRY domain-containing protein 1

2

6

Small-scale

0.611

High

538177

HSP7C
Heat shock cognate 71 kDa protein

2

6

Small-scale

0.611

High

953212

ACTB
Actin, cytoplasmic 1

2

2

Small-scale

0.611

High

995367

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.611

High

1047888

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.611

High

1259602

TBA1A
Tubulin alpha-1A chain

2

6

Small-scale

0.611

High

288148

FOXH1
Forkhead box protein H1

2

2

High-throughput

0.606

High

1139167

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

414922

P53
Cellular tumor antigen p53

2

2

Small-scale

0.602

High

1418776

YTHD1
YTH domain-containing family protein 1

2

0

High-throughput

0.580

High

1144337

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.578

High

1490728

ST38L
Serine/threonine-protein kinase 38-like

1

1

Small-scale

0.578

High

1144516

NONO
Non-POU domain-containing octamer-binding protein

1

2

Small-scale

0.561

High

1186728

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

1337512

TET5D
Terminal nucleotidyltransferase 5D

2

2

High-throughput

0.553

High

1386468

PKHB2
Pleckstrin homology domain-containing family B member 2

2

2

High-throughput

0.553

High

943633

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

2

High-throughput

0.541

High

985975

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.537

High

256711

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

High-throughput

0.536

High

897440

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

931178

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

977866

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.536

High

1201097

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.536

High

682663

S100P
Protein S100-P

1

0

High-throughput

0.513

High

1450881

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

181959

SMAD9
Mothers against decapentaplegic homolog 9

1

4

High-throughput

0.508

High

555541

SKIL
Ski-like protein

1

1

High-throughput

0.508

High

1014677

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.508

High

1028466

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.501

High

1335611

SPRY3
SPRY domain-containing protein 3

1

1

High-throughput

0.489

High

1382415

SPSB4
SPRY domain-containing SOCS box protein 4

1

4

High-throughput

0.489

High

1405079

SORT
Sortilin

1

1

High-throughput

0.489

High

1420086

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.486

High

1157124

NTRK3
NT-3 growth factor receptor

1

2

Small-scale

0.481

High

1449079

ZHANG
CREB/ATF bZIP transcription factor

1

0

Small-scale

0.480

High

408200

TBB4A
Tubulin beta-4A chain

1

5

Small-scale

0.479

High

457802

TBB5
Tubulin beta chain

1

5

Small-scale

0.479

High

468959

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.479

High

475089

VIME
Vimentin

1

1

Small-scale

0.479

High

485543

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.479

High

535720

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

608804

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

651042

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.479

High

668767

APC
Adenomatous polyposis coli protein

1

2

Small-scale

0.479

High

729512

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.479

High

821639

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.479

High

861034

RS10
Small ribosomal subunit protein eS10

1

1

Small-scale

0.479

High

888687

YLPM1
YLP motif-containing protein 1

1

3

Small-scale

0.479

High

899297

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.479

High

965956

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.479

High

969738

RS15A
Small ribosomal subunit protein uS8

1

1

Small-scale

0.479

High

974501

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

Small-scale

0.479

High

974880

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

Small-scale

0.479

High

992409

SKP1
S-phase kinase-associated protein 1

1

3

Small-scale

0.479

High

996904

TBA1B
Tubulin alpha-1B chain

1

6

Small-scale

0.479

High

997208

TBA4A
Tubulin alpha-4A chain

1

5

Small-scale

0.479

High

997581

TBB4B
Tubulin beta-4B chain

1

5

Small-scale

0.479

High

998136

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.479

High

1033331

EWS
RNA-binding protein EWS

1

2

Small-scale

0.479

High

1108772

TBB3
Tubulin beta-3 chain

1

5

Small-scale

0.479

High

1118648

TBB2A
Tubulin beta-2A chain

1

5

Small-scale

0.479

High

1120413

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

Small-scale

0.479

High

1123891

DCTN1
Dynactin subunit 1

1

1

Small-scale

0.479

High

1134577

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

Small-scale

0.479

High

1191507

GRDN
Girdin

1

2

Small-scale

0.479

High

1270808

DDX46
Probable ATP-dependent RNA helicase DDX46

1

1

Small-scale

0.479

High

1287480

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

1338595

SYNE1
Nesprin-1

1

3

Small-scale

0.479

High

1358690

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

Small-scale

0.479

High

1360700

SYNE2
Nesprin-2

1

2

Small-scale

0.479

High

1368341

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.479

High

1420837

TB182
182 kDa tankyrase-1-binding protein

1

4

Small-scale

0.479

High

1458792

SE1L1
Protein sel-1 homolog 1

1

1

Small-scale

0.479

High

1110943

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.464

High

60140

CCD78
Coiled-coil domain-containing protein 78

1

0

Small-scale

0.458

High

332467

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

Small-scale

0.458

High

475476

RS17
Small ribosomal subunit protein eS17

1

0

Small-scale

0.458

High

574535

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

Small-scale

0.458

High

583043

EZRI
Ezrin

1

0

Small-scale

0.458

High

637811

FLNA
Filamin-A

1

0

Small-scale

0.458

High

644163

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

658494

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

692175

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

717008

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

749174

RL9
Large ribosomal subunit protein uL6

1

0

Small-scale

0.458

High

809940

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

814587

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

860654

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.458

High

935351

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

954330

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.458

High

960961

RL15
Large ribosomal subunit protein eL15

1

0

Small-scale

0.458

High

967620

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.458

High

970200

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

972627

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

973009

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

973110

RS29
Small ribosomal subunit protein uS14

1

0

Small-scale

0.458

High

982043

RL23
Large ribosomal subunit protein uL14

1

0

Small-scale

0.458

High

983098

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

986296

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.458

High

994893

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.458

High

1090211

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

0

Small-scale

0.458

High

1136112

PAF15
PCNA-associated factor

1

0

Small-scale

0.458

High

1231894

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

Small-scale

0.458

High

1240410

M18BP
Mis18-binding protein 1

1

0

Small-scale

0.458

High

1358231

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

Small-scale

0.458

High

1386504

CC124
Coiled-coil domain-containing protein 124

1

0

Small-scale

0.458

High

1406968

CDC6
Cell division control protein 6 homolog

1

0

Small-scale

0.458

High

1447708

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

Small-scale

0.458

High

344381

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.445

High

424572

PAI2
Plasminogen activator inhibitor 2

1

4

High-throughput

0.445

High

516221

HS71B
Heat shock 70 kDa protein 1B

1

6

High-throughput

0.445

High

692850

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.445

High

1460508

SPB13
Serpin B13

1

4

High-throughput

0.445

High

1408565

AKAP9
A-kinase anchor protein 9

1

2

Small-scale

0.437

High

1428323

DERL2
Derlin-2

1

1

Small-scale

0.437

High

839650

HUTH
Histidine ammonia-lyase

1

2

High-throughput

0.407

High

1331283

ARL10
ADP-ribosylation factor-like protein 10

1

4

High-throughput

0.407

High

554865

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

2

0

High-throughput

0.313

High

1461738

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.279

Low

337628

FMNL1
Formin-like protein 1

1

0

Small-scale

0.249

Low

876241

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.249

Low

981391

RAB1A
Ras-related protein Rab-1A

1

0

Small-scale

0.249

Low

1125841

FRG1
Protein FRG1

1

0

Small-scale

0.249

Low

1143322

PLEC
Plectin

1

0

Small-scale

0.249

Low

1242795

RL22L
Ribosomal protein eL22-like

1

0

Small-scale

0.249

Low

1361949

TITIN
Titin

1

0

Small-scale

0.249

Low

1439189

Q9HCK3
KIAA1569 protein

1

0

Small-scale

0.249

Low

1490903

TMA7
Translation machinery-associated protein 7

1

0

Small-scale

0.249

Low

69573

A2ML1
Alpha-2-macroglobulin-like protein 1

1

0

High-throughput

0.232

Low

391810

SMR3B
Submaxillary gland androgen-regulated protein 3B

1

0

High-throughput

0.232

Low

999436

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.232

Low

1242375

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.232

Low

1358607

POF1B
Protein POF1B

1

0

High-throughput

0.232

Low

1391239

PGM2
Phosphopentomutase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025