HitPredict

Interactor 1: IKKB (O14920)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK-2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)
Gene: IKBKB

Interactor 2: EPAS1 (Q99814)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
Gene: EPAS1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	26500060
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 756 Hs			1 870
+	Hs
		158486 IKKB_HUMAN (1-756): 0: 662: 100.00		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		158577 IKKB_HUMAN (1-756): 0: 662: 100.00		NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47
+	Hs
		625469 CDK2_HUMAN (12-309): 1.24e-128: 386: 24.84		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		167643 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		NCOA3_HUMAN (6-565): 1.75e-97: 335: 17.47
+	Hs
		167604 IKKA_HUMAN (1-742): 2.48e-177: 527: 50.47		NPAS1_HUMAN (1-522): 8.79e-103: 332: 23.12
+	Hs
		568683 KAPCA_HUMAN (4-283): 2.67e-90: 288: 27.66		HIF1A_HUMAN (3-868): 0: 553: 42.32
+	Hs
		1075398 TBK1_HUMAN (15-370): 8.86e-97: 317: 26.49		NCOA2_HUMAN (6-564): 4.76e-97: 334: 18.53