HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12151521
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Guanylate_kin~Guanylate_kin, Guanylate_kin~PDZ, Guanylate_kin~SH3_1, PDZ~PDZ, Guanylate_kin~SH3_2, PDZ~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 926 Hs			1 724
+	Mm
		1143555 MPP2_MOUSE (347-926): 5.87e-155: 469: 37.48		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		1113136 Q3UP61_MOUSE (405-923): 2.92e-146: 457: 22.06		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Mm
		1143387 DLG1_MOUSE (405-923): 1.81e-145: 456: 22.06		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		159200 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Mm
		251104 CSKP_MOUSE (1-926): 0: 973: 99.89		DLG1_MOUSE (147-465): 2.02e-19: 95.5: 18.54
+	Hs
		159110 CSKP_HUMAN (1-926): 0: 973: 100.00		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		159249 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		1144009 CSKP_RAT (1-926): 0: 945: 97.73		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Hs
		1050419 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42
+	Hs
		1021489 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		1295085 MPP4_HUMAN (354-925): 3.36e-148: 454: 25.62		MPP4_HUMAN (1-279): 6.81e-23: 105: 13.73
+	Hs
		1232481 PALS1_HUMAN (361-925): 9.64e-148: 454: 27.84		PALS1_HUMAN (3-238): 7.09e-18: 90.2: 12.30
+	Hs
		1232493 MPP4_HUMAN (354-925): 3.36e-148: 454: 25.62		PALS1_HUMAN (3-238): 7.09e-18: 90.2: 12.30
+	Dm
		53136 A1Z8G0_DROME (364-925): 1.05e-151: 462: 28.95		DLG1_DROME (194-394): 7.51e-09: 61.3: 18.10
+	Dm
		677679 DLG1_DROME (445-923): 5.3e-145: 456: 21.50		DLG1_DROME (194-394): 7.51e-09: 61.3: 18.10