HitPredict

Interactor 1: CSKP (O14936)
Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)
Gene: CASK

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	14960569, 32296183, 33961781, 32707033, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, validated two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, L27~L27, PDZ~PDZ, PDZ~SH3_2
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0016323 - basolateral plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 926 Hs			1 207
+	Mm
		251089 CSKP_MOUSE (1-926): 0: 973: 99.89		LIN7B_MOUSE (1-207): 1.88e-63: 197: 98.07
+	Hs
		159277 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Mm
		251090 CSKP_MOUSE (1-926): 0: 973: 99.89		LIN7C_MOUSE (1-196): 9.63e-58: 182: 84.69
+	Hs
		158254 CSKP_HUMAN (1-926): 0: 973: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		159203 CSKP_HUMAN (1-926): 0: 973: 100.00		SNTB2_HUMAN (2-207): 1.48e-36: 135: 28.10
+	Hs
		159207 CSKP_HUMAN (1-926): 0: 973: 100.00		SNTB1_HUMAN (2-206): 4.53e-34: 128: 23.94
+	Hs
		159110 CSKP_HUMAN (1-926): 0: 973: 100.00		CSKP_HUMAN (10-206): 4.77e-31: 121: 20.00
+	Hs
		159190 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Hs
		159200 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Mm
		251104 CSKP_MOUSE (1-926): 0: 973: 99.89		DLG1_MOUSE (67-191): 1.67e-22: 96.7: 29.77
+	Hs
		159249 CSKP_HUMAN (1-926): 0: 973: 100.00		DLG3_HUMAN (29-164): 2.29e-20: 90.3: 25.53
+	Rn
		1144009 CSKP_RAT (1-926): 0: 945: 97.73		DLG1_RAT (57-191): 8.24e-25: 103: 25.71
+	Dm
		1096800 CSKP_DROME (1-926): 0: 835: 60.38		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Ce
		873636 LIN2_CAEEL (2-926): 0: 744: 45.21		Q9U245_CAEEL (9-206): 5.71e-47: 155: 65.66
+	Dm
		116476 M9PJD0_DROME (287-926): 2.45e-154: 500: 24.89		Q9VBY7_DROME (1-195): 1.92e-53: 171: 77.44
+	Hs
		1050415 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		1050418 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158282 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Mm
		1143555 MPP2_MOUSE (347-926): 5.87e-155: 469: 37.48		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Hs
		1021489 MPP2_HUMAN (420-926): 8.18e-154: 466: 39.27		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92