HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: NSD2 (O96028)
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)
Gene: NSD2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	30013191
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 1365
+	Hs
		682013 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		NSD3_HUMAN (116-1340): 0: 758: 45.19
+	Hs
		160716 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		EHMT2_HUMAN (889-1199): 3.73e-54: 209: 20.65
+	Hs
		160759 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74
+	Hs
		681867 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		EZH2_HUMAN (904-1188): 5.39e-59: 220: 22.48
+	Hs
		1292201 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		SETD2_HUMAN (852-1238): 1.1e-53: 209: 27.74
+	Hs
		152597 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		KMT2D_HUMAN (69-660): 1.16e-09: 65.7: 8.54