HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: MYCL (P12524)
Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog)
Gene: MYCL

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 364
+	Hs
		160313 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		MYC_HUMAN (1-362): 1e-76: 245: 29.75
+	Hs
		160320 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		MYCN_HUMAN (1-362): 2.43e-63: 210: 31.05
+	Hs
		346044 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		MYC_HUMAN (1-362): 1e-76: 245: 29.75
+	Hs
		347580 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYC_HUMAN (1-362): 1e-76: 245: 29.75
+	Hs
		379721 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		MYCN_HUMAN (1-362): 2.43e-63: 210: 31.05
+	At
		1105320 KIN10_ARATH (132-400): 5.34e-140: 410: 33.21		MYC2_ARATH (123-363): 4.94e-33: 131: 18.55
+	Hs
		681801 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		MAD1_HUMAN (239-361): 4.51e-27: 108: 21.95
+	At
		1122927 CIPKO_ARATH (125-389): 2.22e-133: 391: 32.46		FAMA_ARATH (197-346): 9.28e-27: 111: 15.33