HitPredict

Interactor 1: AURKA (O14965)
Aurora kinase A (EC 2.7.11.1) (Aurora 2) (Aurora/IPL1-related kinase 1) (ARK-1) (Aurora-related kinase 1) (Breast tumor-amplified kinase) (Ipl1- and aurora-related kinase 1) (Serine/threonine-protein kinase 15) (Serine/threonine-protein kinase 6) (Serine/threonine-protein kinase Ayk1) (Serine/threonine-protein kinase aurora-A)
Gene: AURKA

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 403 Hs			1 582
+	Hs
		160685 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Rn
		1144336 AKT3_RAT (29-401): 9.76e-139: 406: 23.76		PABP1_RAT (1-405): 6.25e-40: 156: 10.05
+	Hs
		568649 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516351 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		568713 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		1292216 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PABP3_HUMAN (1-333): 6.27e-42: 162: 10.11
+	Hs
		1031427 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		516639 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		160630 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		160587 AURKA_HUMAN (1-403): 2.51e-162: 463: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Mm
		554885 KPCE_MOUSE (4-401): 1.29e-136: 409: 24.57		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1288614 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		1292251 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Hs
		969086 KPCE_HUMAN (4-401): 3.82e-137: 410: 24.33		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		681862 AKT1_HUMAN (27-401): 3.06e-138: 404: 25.07		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		568707 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		568677 KAPCA_HUMAN (117-400): 5.82e-136: 394: 29.76		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		1162647 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1077453 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		1119143 AURKB_HUMAN (126-395): 6.86e-131: 381: 71.43		PAP1L_HUMAN (2-131): 1.6e-11: 69.2: 11.54