Protein: YHI0
Putative proline--tRNA ligase YHR020W (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)

Gene: YHI0, YHR020W
Organism: Saccharomyces cerevisiae S288C
Interactions: 202
UniProt ID: P38708

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004827 - proline-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006433 - prolyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

388977

SYTC
Threonine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.618

High

425077

SYH
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.618

High

744038

SYG
Glycine--tRNA ligase 1, mitochondrial

1

9

High-throughput

0.618

High

752820

SYNC
Asparagine--tRNA ligase, cytoplasmic

2

8

High-throughput

0.611

High

402941

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

2

1

Small-scale

0.584

High

524286

CAF20
Cap-associated protein CAF20

2

1

High-throughput

0.584

High

680676

HS104
Heat shock protein 104

2

4

High-throughput

0.584

High

752914

ATAD2
ATPase histone chaperone YTA7

2

1

High-throughput

0.571

High

502993

SEC7
Protein transport protein SEC7

2

1

High-throughput

0.567

High

752921

LCB2
Serine palmitoyltransferase 2

2

1

High-throughput

0.537

High

752950

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

752960

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

628010

SIS1
Protein SIS1

2

5

High-throughput

0.533

High

752925

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

4

High-throughput

0.533

High

752927

SA155
SIT4-associating protein SAP155

2

1

High-throughput

0.533

High

498513

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.513

High

752913

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.513

High

412978

KAPB
cAMP-dependent protein kinase type 2

1

2

High-throughput

0.500

High

579418

GBB
Guanine nucleotide-binding protein subunit beta

1

4

High-throughput

0.500

High

604261

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.500

High

623816

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.500

High

632529

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.500

High

689336

ARP2
Actin-related protein 2

1

1

High-throughput

0.500

High

692658

DUR1
Urea amidolyase [Includes: Urea carboxylase

1

1

High-throughput

0.500

High

752963

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.500

High

748339

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.489

High

752917

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

752976

UTP13
U3 small nucleolar RNA-associated protein 13

1

5

High-throughput

0.489

High

704333

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

746492

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

141308

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

343827

SYMC
Methionine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

366232

HSP82
ATP-dependent molecular chaperone HSP82

1

9

High-throughput

0.479

High

389085

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

407022

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

410371

SC160
Protein SCP160

1

1

High-throughput

0.479

High

430775

SYV
Valine--tRNA ligase, mitochondrial

1

9

High-throughput

0.479

High

482241

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

526336

SYQ
Glutamine--tRNA ligase

1

6

High-throughput

0.479

High

543676

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.479

High

546170

SYKC
Lysine--tRNA ligase, cytoplasmic

1

9

High-throughput

0.479

High

560965

EF3A
Elongation factor 3A

1

6

High-throughput

0.479

High

615263

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.479

High

631852

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

643667

SYLC
Leucine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

668194

EF1G1
Elongation factor 1-gamma 1

1

2

High-throughput

0.479

High

690527

CDC12
Cell division control protein 12

1

1

High-throughput

0.479

High

692511

ZUO1
Zuotin

1

6

High-throughput

0.479

High

700873

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

703605

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

729888

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

730622

EF1G2
Elongation factor 1-gamma 2

1

2

High-throughput

0.479

High

734830

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

742772

GBLP
Small ribosomal subunit protein RACK1

1

4

High-throughput

0.479

High

746566

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.479

High

752426

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

752895

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

752896

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.479

High

752903

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

752905

RV167
Reduced viability upon starvation protein 167

1

5

High-throughput

0.479

High

752909

ARB1
ABC transporter ATP-binding protein ARB1

1

5

High-throughput

0.479

High

752916

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

752924

GCN20
Protein GCN20

1

5

High-throughput

0.479

High

752926

LSB3
LAS seventeen-binding protein 3

1

2

High-throughput

0.479

High

752928

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

6

High-throughput

0.479

High

752929

ARC1
tRNA-aminoacylation cofactor ARC1

1

4

High-throughput

0.479

High

752932

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

752936

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

752944

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

752945

SPC98
Spindle pole body component SPC98

1

1

High-throughput

0.479

High

752948

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.479

High

752949

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.479

High

752952

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.479

High

752953

PDR16
Phosphatidylinositol transfer protein PDR16

1

1

High-throughput

0.479

High

752962

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

752968

RLI1
Translation initiation factor RLI1

1

4

High-throughput

0.479

High

752973

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

752975

MYO5
Myosin-5

1

3

High-throughput

0.479

High

752980

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

5

Small-scale

0.479

High

752986

NEW1
[NU+] prion formation protein 1

1

5

High-throughput

0.479

High

752987

KEL3
Kelch repeat-containing protein 3

1

1

High-throughput

0.479

High

368022

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.458

High

407891

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

638740

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.458

High

710329

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.458

High

731569

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

748132

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

752898

IF1A
Eukaryotic translation initiation factor 1A

1

0

High-throughput

0.458

High

752900

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.458

High

752933

DENR
Translation machinery-associated protein 22

1

0

High-throughput

0.458

High

752958

TMA20
Translation machinery-associated protein 20

1

0

High-throughput

0.458

High

752966

ESP1
Separin

1

0

High-throughput

0.458

High

752972

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

752977

BCP1
Protein BCP1

1

0

High-throughput

0.458

High

752982

LAM6
Membrane-anchored lipid-binding protein LAM6

1

0

High-throughput

0.458

High

752983

SGO1
Shugoshin

1

0

High-throughput

0.458

High

752990

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

752992

MDY2
Ubiquitin-like protein MDY2

1

0

High-throughput

0.458

High

539980

EI2BA
Translation initiation factor eIF2B subunit alpha

1

1

High-throughput

0.457

High

691789

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.457

High

744610

TAF5
Transcription initiation factor TFIID subunit 5

1

2

High-throughput

0.457

High

752920

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.457

High

752922

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.457

High

752947

COPA
Coatomer subunit alpha

1

3

High-throughput

0.457

High

493872

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

511179

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

605732

NPR1
Nitrogen permease reactivator protein

1

6

High-throughput

0.445

High

752923

EMW1
Essential for maintenance of the cell wall protein 1

1

4

High-throughput

0.445

High

752946

MPA43
Protein MPA43

1

1

High-throughput

0.445

High

752951

HCH1
Hsp90 co-chaperone HCH1

1

1

High-throughput

0.445

High

752965

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.445

High

752974

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.445

High

752981

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.445

High

752994

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.445

High

752997

DUF1
DUB-associated factor 1

1

6

High-throughput

0.445

High

405600

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

413482

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

423016

TOM70
Mitochondrial import receptor subunit TOM70

1

5

High-throughput

0.437

High

471032

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

581105

IF5A2
Eukaryotic translation initiation factor 5A-2

1

2

High-throughput

0.437

High

606632

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.437

High

662126

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

689619

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.437

High

692774

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

700386

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.437

High

701645

SRPR
Signal recognition particle receptor subunit alpha homolog

1

1

High-throughput

0.437

High

750122

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.437

High

752897

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.437

High

752899

SEC31
Protein transport protein SEC31

1

3

High-throughput

0.437

High

752902

CAJ1
Protein CAJ1

1

6

High-throughput

0.437

High

752904

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

752907

SIT1
Siderophore iron transporter 1

1

2

High-throughput

0.437

High

752935

HOSC
Homocitrate synthase, cytosolic isozyme

1

2

High-throughput

0.437

High

752937

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

752943

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

752956

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

752959

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

752961

MAP1
Methionine aminopeptidase 1

1

1

High-throughput

0.437

High

752971

YMC0
Uncharacterized protein YML020W

1

1

High-throughput

0.437

High

752978

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

752984

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

752985

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

752991

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

593230

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.426

High

733429

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.426

High

733695

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.426

High

752894

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.426

High

752906

SLN1
Osmosensing histidine protein kinase SLN1

1

0

High-throughput

0.426

High

752910

MGDP1
Putative magnesium-dependent phosphatase YER134C

1

0

High-throughput

0.426

High

752911

VID27
Vacuolar import and degradation protein 27

1

0

High-throughput

0.426

High

752941

ARI1
NADPH-dependent aldehyde reductase ARI1

1

0

High-throughput

0.426

High

752954

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

752955

SIW14
Inositol phosphatase SIW14

1

0

High-throughput

0.426

High

752967

FDC1
Ferulic acid decarboxylase 1

1

0

High-throughput

0.426

High

752969

YM44
Uncharacterized protein YMR178W

1

0

High-throughput

0.426

High

752993

MAM3
Protein MAM3

1

0

High-throughput

0.426

High

427238

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.407

High

617406

MRS4
Mitochondrial RNA-splicing protein MRS4

1

1

High-throughput

0.407

High

659157

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.407

High

690506

HXT4
Low-affinity glucose transporter HXT4

1

1

High-throughput

0.407

High

752901

HXT7
High-affinity hexose transporter HXT7

1

1

High-throughput

0.407

High

752912

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.407

High

752938

PHB2
Prohibitin-2

1

2

High-throughput

0.407

High

701208

SUI1
Eukaryotic translation initiation factor eIF-1

2

0

High-throughput

0.310

High

743981

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

2

0

High-throughput

0.307

High

516798

SST2
Protein SST2

1

0

High-throughput

0.279

Low

563956

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.279

Low

690774

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.279

Low

429693

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

358043

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

383122

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

425927

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

472169

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

480081

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480648

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

549048

TRM1
tRNA

1

0

High-throughput

0.249

Low

645420

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

706250

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

732707

RL14A
Large ribosomal subunit protein eL14A

1

0

High-throughput

0.249

Low

752908

IRC22
Increased recombination centers protein 22

1

0

High-throughput

0.249

Low

752919

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

752957

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.249

Low

752979

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

752988

TRMB
tRNA

1

0

High-throughput

0.249

Low

520257

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.232

Low

576227

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low

596973

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.232

Low

606330

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

731652

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.232

Low

752915

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.232

Low

752918

ICE2
Protein ICE2

1

0

High-throughput

0.232

Low

752930

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.232

Low

752931

NU192
Nucleoporin NUP192

1

0

High-throughput

0.232

Low

752934

SEC16
COPII coat assembly protein SEC16

1

0

High-throughput

0.232

Low

752939

NU188
Nucleoporin NUP188

1

0

High-throughput

0.232

Low

752940

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.232

Low

752942

YG1I
Uncharacterized membrane protein YGR026W

1

0

High-throughput

0.232

Low

752964

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.232

Low

752970

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

0

High-throughput

0.232

Low

752989

FSF1
Sideroflexin FSF1

1

0

High-throughput

0.232

Low

752995

NOP58
Nucleolar protein 58

1

0

High-throughput

0.232

Low

752996

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024