Protein: IRS1
Insulin receptor substrate 1 (IRS-1)

Gene: IRS1
Organism: Mus musculus
Interactions: 64
UniProt ID: P35569

Gene Ontology (top 5):
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

686938

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

13

20

Small-scale

0.755

High

772558

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.647

High

772560

CRK
Adapter molecule crk

1

20

Small-scale

0.647

High

772568

KS6B1
Ribosomal protein S6 kinase beta-1

1

6

Small-scale

0.647

High

581954

INSR
Insulin receptor

1

20

Small-scale

0.618

High

772547

IRS2
Insulin receptor substrate 2

1

13

Small-scale

0.618

High

772551

KPCZ
Protein kinase C zeta type

1

8

Small-scale

0.618

High

772553

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

13

Small-scale

0.618

High

772556

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

772571

ASPP2
Apoptosis-stimulating of p53 protein 2

1

14

Small-scale

0.618

High

772574

PHIP
PH-interacting protein

1

11

Small-scale

0.618

High

772576

MK08
Mitogen-activated protein kinase 8

1

8

Small-scale

0.618

High

772585

MK09
Mitogen-activated protein kinase 9

1

8

Small-scale

0.618

High

772536

RAB6B
Ras-related protein Rab-6B

1

7

Small-scale

0.575

High

772539

RAN
GTP-binding nuclear protein Ran

1

8

Small-scale

0.575

High

772552

EPHA2
Ephrin type-A receptor 2

1

20

Small-scale

0.575

High

628482

VIME
Vimentin

2

7

Small-scale

0.571

High

772538

1433E
14-3-3 protein epsilon

2

11

Small-scale

0.571

High

772579

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.552

High

772542

FBX40
F-box only protein 40

1

0

Small-scale

0.537

High

480960

NUCL
Nucleolin

1

12

Small-scale

0.529

High

772555

TRI72
Tripartite motif-containing protein 72

1

4

Small-scale

0.489

High

772545

PHB1
Prohibitin 1

1

4

Small-scale

0.484

High

772550

CTNB1
Catenin beta-1

1

8

Small-scale

0.484

High

772564

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

4

Small-scale

0.484

High

147719

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

382452

P53
Cellular tumor antigen p53

1

9

Small-scale

0.479

High

772534

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

8

Small-scale

0.479

High

772540

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

772546

HDAC2
Histone deacetylase 2

1

15

Small-scale

0.479

High

772549

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

772554

RAD51
DNA repair protein RAD51 homolog 1

1

2

Small-scale

0.479

High

772561

SQSTM
Sequestosome-1

1

8

Small-scale

0.479

High

772562

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

Small-scale

0.479

High

772572

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.479

High

772578

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

12

Small-scale

0.479

High

772583

CUL3
Cullin-3

1

15

Small-scale

0.479

High

772586

CUL1
Cullin-1

1

15

Small-scale

0.479

High

534009

H10
Histone H1.0

1

0

Small-scale

0.464

High

547238

HS90B
Heat shock protein HSP 90-beta

1

6

Small-scale

0.445

High

576854

RLA0
Large ribosomal subunit protein uL10

1

2

Small-scale

0.445

High

723720

CTND1
Catenin delta-1

1

12

Small-scale

0.445

High

772535

AFF3
AF4/FMR2 family member 3

1

11

Small-scale

0.445

High

772537

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

Small-scale

0.445

High

772541

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.445

High

772543

YBOX1
Y-box-binding protein 1

1

2

Small-scale

0.445

High

772544

HSP7C
Heat shock cognate 71 kDa protein

1

4

Small-scale

0.445

High

772559

CAVN2
Caveolae-associated protein 2

1

1

Small-scale

0.445

High

772563

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

Small-scale

0.445

High

772565

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

Small-scale

0.445

High

772566

IPO8
Importin-8

1

2

Small-scale

0.445

High

772569

Q8BYC8
Scm polycomb group protein-like 2

1

8

Small-scale

0.445

High

772570

LIPB1
Liprin-beta-1

1

5

Small-scale

0.445

High

772575

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

14

Small-scale

0.445

High

772577

IPO9
Importin-9

1

4

Small-scale

0.445

High

772582

CNOT9
CCR4-NOT transcription complex subunit 9

1

2

Small-scale

0.445

High

772584

TEN3
Teneurin-3

1

3

Small-scale

0.445

High

398131

CFAD
Complement factor D

1

1

High-throughput

0.437

High

772548

UNG
Uracil-DNA glycosylase

1

0

Small-scale

0.426

High

772580

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

Small-scale

0.426

High

772557

FLOT2
Flotillin-2

1

6

Small-scale

0.407

High

772573

RFC3
Replication factor C subunit 3

1

3

Small-scale

0.407

High

772581

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

Small-scale

0.407

High

772567

PDIP3
Polymerase delta-interacting protein 3

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025