HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	15545284, 16243315
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1030 Hs			1 1025
+	Hs
		1167443 ANR50_HUMAN (22-935): 8.69e-65: 241: 13.09		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		161453 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Hs
		161388 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		148138 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		1167417 PP12C_HUMAN (538-1030): 4.93e-33: 139: 20.35		MPRIP_HUMAN (1-1025): 9.29e-127: 412: 100.00
+	Hs
		161319 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Mm
		936588 ANS1B_MOUSE (44-836): 6.65e-73: 265: 15.88		ROCK2_MOUSE (502-969): 1.57e-40: 165: 18.71
+	Hs
		1206058 MIB1_HUMAN (41-304): 3.48e-51: 198: 21.75		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		1189816 ANR50_HUMAN (22-935): 8.69e-65: 241: 13.09		MYH14_HUMAN (595-972): 3.69e-09: 63.1: 14.89
+	Hs
		1021434 ANK3_HUMAN (159-354): 1.67e-13: 77.6: 15.23		DLG5_HUMAN (647-1019): 8.88e-54: 207: 21.61
+	Hs
		1357766 INVS_HUMAN (156-372): 1.99e-17: 89.8: 13.64		CE164_HUMAN (163-980): 5.02e-36: 150: 11.93
+	Dm
		1303397 Q9VJ14_DROME (140-612): 6.22e-24: 111: 14.07		MYSN_DROME (457-975): 1.82e-17: 90.5: 15.79
+	Hs
		225128 MYPT2_HUMAN (1-905): 6.08e-21: 101: 11.37		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Mm
		57429 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MYH9_MOUSE (542-1025): 4.68e-18: 92.5: 8.68
+	Rn
		251022 ANK3_RAT (159-354): 1.12e-15: 84.6: 15.74		PLEC_RAT (552-958): 2.26e-13: 77.4: 13.74
+	Mm
		57440 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		PLEC_MOUSE (494-979): 2.14e-11: 70.8: 14.60
+	Mm
		57416 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		Q6S385_MOUSE (494-979): 3.17e-11: 70.1: 14.60
+	Mm
		57397 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		Q3UFT0_MOUSE (773-1013): 4.15e-10: 66.3: 13.69
+	Hs
		1021404 ANK3_HUMAN (159-354): 1.67e-13: 77.6: 15.23		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96