Protein: SET1B
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)

Gene: SET1B, SETD1B
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q9UPS6

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458472

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

11

20

Small-scale

0.979

High

1454063

CXXC1
CXXC-type zinc finger protein 1

11

19

Small-scale

0.975

High

1145563

RBBP5
Retinoblastoma-binding protein 5

10

20

Small-scale

0.974

High

1250059

WDR82
WD repeat-containing protein 82

5

20

Small-scale

0.909

High

998948

H31
Histone H3.1

3

20

Small-scale

0.845

High

965335

WDR5
WD repeat-containing protein 5

12

20

Small-scale

0.760

High

175951

SET1A
Histone-lysine N-methyltransferase SETD1A

2

17

Small-scale

0.754

High

250898

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.691

High

1313188

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

4

High-throughput

0.691

High

1366144

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

9

High-throughput

0.691

High

938145

ANM2
Protein arginine N-methyltransferase 2

3

5

High-throughput

0.667

High

1258981

H32
Histone H3.2

1

20

Small-scale

0.647

High

872051

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

3

High-throughput

0.628

High

161526

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.618

High

224399

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

667513

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

12

Small-scale

0.618

High

1041625

KMT2A
Histone-lysine N-methyltransferase 2A

1

18

High-throughput

0.618

High

1338286

KMT2C
Histone-lysine N-methyltransferase 2C

1

17

High-throughput

0.618

High

1339041

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

1462038

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

1420482

DPY30
Protein dpy-30 homolog

2

7

High-throughput

0.611

High

1459014

DAXX
Death domain-associated protein 6

2

3

High-throughput

0.601

High

1335404

CAMKV
CaM kinase-like vesicle-associated protein

1

4

High-throughput

0.575

High

286509

WBP4
WW domain-binding protein 4

1

3

High-throughput

0.536

High

1029785

FOXK2
Forkhead box protein K2

1

8

Small-scale

0.536

High

1214687

RBM26
RNA-binding protein 26

1

14

High-throughput

0.536

High

596426

H12
Histone H1.2

1

18

High-throughput

0.515

High

1037442

H11
Histone H1.1

1

18

High-throughput

0.515

High

71487

P20L1
PHD finger protein 20-like protein 1

1

10

High-throughput

0.479

High

129560

MEN1
Menin

1

7

High-throughput

0.479

High

143332

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

174415

ZN609
Zinc finger protein 609

1

18

High-throughput

0.479

High

194630

KDM6A
Lysine-specific demethylase 6A

1

20

High-throughput

0.479

High

373509

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

378526

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.479

High

414861

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

474379

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

696873

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

769526

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

905515

HCFC1
Host cell factor 1

1

20

High-throughput

0.479

High

928365

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

942961

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

15

High-throughput

0.479

High

1088105

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1130610

NCOA6
Nuclear receptor coactivator 6

1

20

High-throughput

0.479

High

1257172

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

1276123

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

1315076

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

1329949

SIR6
NAD-dependent protein deacylase sirtuin-6

1

10

High-throughput

0.479

High

1338715

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

20

High-throughput

0.479

High

1357609

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

1390192

MCRS1
Microspherule protein 1

1

4

High-throughput

0.479

High

1394246

BOD1
Biorientation of chromosomes in cell division protein 1

1

8

High-throughput

0.479

High

1415302

PHF20
PHD finger protein 20

1

20

High-throughput

0.479

High

1435969

KAT8
Histone acetyltransferase KAT8

1

7

High-throughput

0.479

High

1436244

CSR2B
Cysteine-rich protein 2-binding protein

1

20

High-throughput

0.479

High

1437170

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

1449162

MBIP1
MAP3K12-binding inhibitory protein 1

1

3

High-throughput

0.479

High

1454740

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

1454811

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

1461537

ZN608
Zinc finger protein 608

1

12

High-throughput

0.479

High

1461644

YETS2
YEATS domain-containing protein 2

1

20

High-throughput

0.479

High

1462559

HCFC2
Host cell factor 2

1

20

High-throughput

0.479

High

1415911

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

639181

SYT1
Synaptotagmin-1

1

1

High-throughput

0.445

High

1054159

BTK
Tyrosine-protein kinase BTK

1

12

High-throughput

0.445

High

1369324

EDA
Ectodysplasin-A

1

1

High-throughput

0.407

High

1433656

E41L1
Band 4.1-like protein 1

1

10

High-throughput

0.407

High

921512

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025