HitPredict

Interactor 1: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Interactor 2: ANM5 (O14744)
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
Gene: PRMT5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 11152681, 10531356, 35046516, 31839598, 22365833, 23071334, 11756452
Identification Methods affinity chromatography technology, cross-linking study, two hybrid, biochemical, pull down, molecular sieving
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PRMT5~PRMT5_C, PRMT5~PRMT5_TIM, PRMT5_C~PRMT5_C, PRMT5_C~PRMT5_TIM
Common GO terms GO:0000387 - spliceosomal snRNP assembly
GO:0000785 - chromatin
GO:0002039 - p53 binding
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
and 34 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 637
Hs

1 637
+ Hs
+ Hs
+ Sp
+ Ce
+ Sc
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ At
+ At
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025