Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: NU214 (P35658)
Nuclear pore complex protein Nup214 (214 kDa nucleoporin) (Nucleoporin Nup214) (Protein CAN)
Gene: NUP214

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.918

The method score is based on:

Property Details
Experiments 27613868, 11425870, 35271311, 37516964, 15239126
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains CRM1_C~Nup214_FG, IBN_N~Nup214_FG, Nup214_FG~Xpo1
Common GO terms GO:0005049 - nuclear export signal receptor activity
GO:0005635 - nuclear envelope
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006406 - mRNA export from nucleus
and 2 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1071
Hs

1 2090
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Sc
+ Tt
+ Xl
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc
+ Hs
+ Hs
+ Xl
+ Sc

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Last updated: 15 Jul 2024