Protein: C1TC
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) (Epididymis secretory sperm binding protein) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]

Gene: C1TC, MTHFD1
Organism: Homo sapiens
Interactions: 231
UniProt ID: P11586

Gene Ontology (top 5):
GO:0001780 - neutrophil homeostasis
GO:0001843 - neural tube closure
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

240600

PRKN
E3 ubiquitin-protein ligase parkin

4

4

High-throughput

0.686

High

547541

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.650

High

395391

ESR1
Estrogen receptor

3

2

Small-scale

0.641

High

547605

CUL3
Cullin-3

2

3

High-throughput

0.611

High

547596

AHNK
Neuroblast differentiation-associated protein AHNAK

2

1

High-throughput

0.601

High

547550

CDK2
Cyclin-dependent kinase 2

2

1

High-throughput

0.584

High

547707

PD1L1
Programmed cell death 1 ligand 1

2

1

Small-scale

0.584

High

547544

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

547545

RO52
E3 ubiquitin-protein ligase TRIM21

2

0

Small-scale

0.559

High

547592

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

468007

HS90B
Heat shock protein HSP 90-beta

1

7

Small-scale

0.536

High

484347

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

547562

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

547580

ARP2
Actin-related protein 2

1

1

High-throughput

0.536

High

547583

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

547604

CUL2
Cullin-2

1

3

High-throughput

0.536

High

547641

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

547659

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

547699

PAK6
Serine/threonine-protein kinase PAK 6

1

2

High-throughput

0.536

High

547726

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

371031

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

547542

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.533

High

547553

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

1

High-throughput

0.533

High

547559

RFA3
Replication protein A 14 kDa subunit

2

1

High-throughput

0.533

High

547549

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.515

High

547564

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

547724

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.515

High

135463

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

213786

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

361085

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

400200

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.513

High

470249

NEP
Neprilysin

1

0

Small-scale

0.513

High

528955

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

547593

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

547601

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.513

High

547671

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

547676

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

547711

DUX4
Double homeobox protein 4

1

0

High-throughput

0.494

High

547556

CNR2
Cannabinoid receptor 2

1

2

Small-scale

0.489

High

547660

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.489

High

131697

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.479

High

162448

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.479

High

188799

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.479

High

226691

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

2

High-throughput

0.479

High

293120

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

315057

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

319343

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

349760

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

411263

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

425278

ISG15
Ubiquitin-like protein ISG15

1

2

High-throughput

0.479

High

458256

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

461080

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

507471

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

536385

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

547554

PML
Protein PML

1

5

High-throughput

0.479

High

547555

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

547557

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

547558

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

547566

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

547568

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

547571

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

547575

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

1

High-throughput

0.479

High

547579

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

547584

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

547585

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

547586

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

547587

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.479

High

547597

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

547600

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

547602

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

547603

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

547606

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.479

High

547609

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

547613

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

547614

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

547615

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.479

High

547616

NONO
Non-POU domain-containing octamer-binding protein

1

2

Small-scale

0.479

High

547618

CRY1
Cryptochrome-1

1

1

High-throughput

0.479

High

547619

DDR2
Discoidin domain-containing receptor 2

1

3

High-throughput

0.479

High

547620

CRY2
Cryptochrome-2

1

1

High-throughput

0.479

High

547636

ZFY16
Zinc finger FYVE domain-containing protein 16

1

2

Small-scale

0.479

High

547637

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

547640

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

547648

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

547649

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

547652

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

547654

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

547656

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.479

High

547662

TITIN
Titin

1

1

High-throughput

0.479

High

547665

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

547666

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

547667

ARMC5
Armadillo repeat-containing protein 5

1

3

High-throughput

0.479

High

547669

SPDLY
Protein Spindly

1

2

High-throughput

0.479

High

547672

CI072
Guanine nucleotide exchange factor C9orf72

1

2

High-throughput

0.479

High

547674

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

547677

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

547679

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

547680

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

547684

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

547685

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

4

High-throughput

0.479

High

547689

GAN
Gigaxonin

1

2

High-throughput

0.479

High

547690

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

547693

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.479

High

547696

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

547697

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

547698

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

547700

ANLN
Anillin

1

2

High-throughput

0.479

High

547710

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

547712

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

547713

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

547714

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

547716

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

547719

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

547723

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

547725

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

547704

DJC17
DnaJ homolog subfamily C member 17

1

2

High-throughput

0.470

High

547708

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.470

High

136800

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

159487

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

324468

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

379844

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

413084

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

547540

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

547547

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

547551

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

547570

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

547572

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

547573

IST1
IST1 homolog

1

0

High-throughput

0.458

High

547574

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

547578

CD81
CD81 antigen

1

0

High-throughput

0.458

High

547588

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

547589

CCNA1
Cyclin-A1

1

0

High-throughput

0.458

High

547591

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

547599

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

547610

CUL7
Cullin-7

1

0

High-throughput

0.458

High

547624

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

547625

GRAM4
GRAM domain-containing protein 4

1

0

Small-scale

0.458

High

547626

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

547627

CDC73
Parafibromin

1

0

High-throughput

0.458

High

547628

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

547629

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

547638

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

547650

DYHC2
Cytoplasmic dynein 2 heavy chain 1

1

0

High-throughput

0.458

High

547653

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

547655

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

547658

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

0

Small-scale

0.458

High

547664

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

547673

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

547678

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

547682

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

547688

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

547691

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

547702

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

547717

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

547721

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

547722

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

547581

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

547694

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.457

High

327764

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

354514

PAK4
Serine/threonine-protein kinase PAK 4

1

2

High-throughput

0.445

High

397886

ANGI
Angiogenin

1

1

High-throughput

0.445

High

547577

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

547595

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.445

High

547598

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

547621

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

547630

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.445

High

547651

RN169
E3 ubiquitin-protein ligase RNF169

1

2

Small-scale

0.445

High

547687

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

547692

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

142801

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.437

High

259359

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.437

High

473751

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.437

High

547543

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.437

High

547552

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.437

High

547560

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

547561

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.437

High

547563

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.437

High

547567

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

547608

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

547611

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.437

High

547612

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.437

High

547617

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

547622

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

2

Small-scale

0.437

High

547623

OTUD1
OTU domain-containing protein 1

1

1

High-throughput

0.437

High

547631

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

547634

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

547635

KCTD9
BTB/POZ domain-containing protein KCTD9

1

1

High-throughput

0.437

High

547642

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

547643

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.437

High

547644

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

547657

FBX25
F-box only protein 25

1

1

High-throughput

0.437

High

547675

RING2
E3 ubiquitin-protein ligase RING2

1

4

High-throughput

0.437

High

547681

YTHD1
YTH domain-containing family protein 1

1

1

High-throughput

0.437

High

547683

TRI55
Tripartite motif-containing protein 55

1

8

High-throughput

0.437

High

547686

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

547695

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

547701

ANM8
Protein arginine N-methyltransferase 8

1

4

Small-scale

0.437

High

547705

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

547706

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

547709

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

547715

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.437

High

547720

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

904

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

547546

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

547548

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

547565

MTHR
Methylenetetrahydrofolate reductase

1

0

Small-scale

0.426

High

547582

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

547594

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

547670

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

547718

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

429203

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

547569

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

547703

CAH10
Carbonic anhydrase-related protein 10

2

0

High-throughput

0.318

High

547607

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.279

Low

352897

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

547639

IQCH
IQ domain-containing protein H

1

0

High-throughput

0.269

Low

246412

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.261

Low

105209

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

243846

K0513
Uncharacterized protein KIAA0513

1

0

High-throughput

0.249

Low

377166

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

426436

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.249

Low

547576

AF10
Protein AF-10

1

0

High-throughput

0.249

Low

547590

NDP
Norrin

1

0

Small-scale

0.249

Low

547632

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

547633

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

547646

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

547647

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

547663

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

547668

S7A6O
Probable RNA polymerase II nuclear localization protein SLC7A6OS

1

0

High-throughput

0.249

Low

547645

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

547661

CTR3
Cationic amino acid transporter 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025