HitPredict

Interactor 1: XPO1 (O14980)
Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
Gene: XPO1

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	26673895
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~Xpo1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1071 Hs			1 248
+	Hs
		162697 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		162698 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		162372 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Xl
		1155687 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		Q7ZWX7_XENLA (15-98): 5.16e-35: 125: 44.71
+	Hs
		162812 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PAP1L_HUMAN (17-148): 9.11e-22: 95.4: 18.80
+	Hs
		162790 XPO1_HUMAN (1-1071): 0: 1022: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		162702 XPO1_HUMAN (1-1071): 0: 1022: 100.00		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Hs
		162636 XPO1_HUMAN (1-1071): 0: 1022: 100.00		TIAR_HUMAN (113-202): 2.85e-10: 61.5: 12.63
+	Xl
		1155766 Q6NS03_XENLA (1-1071): 0: 1007: 97.01		EPABA_XENLA (123-200): 4.64e-12: 67.3: 14.12
+	Sc
		376677 XPO1_YEAST (14-1067): 0: 848: 46.08		PABP_YEAST (123-203): 2.42e-12: 68.1: 22.73
+	Mm
		1321934 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF9_MOUSE (2-239): 1.21e-65: 204: 58.82
+	Mm
		192626 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF5_MOUSE (14-183): 7.35e-61: 194: 41.48
+	Mm
		1112120 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF6_MOUSE (17-200): 4.04e-56: 184: 40.51
+	Mm
		1257560 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF4_MOUSE (17-198): 4.98e-49: 169: 42.47
+	Mm
		1161051 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF1_MOUSE (1-235): 1.04e-49: 165: 100.00
+	At
		186863 MOS14_ARATH (26-1002): 6.38e-104: 350: 13.35		SR34_ARATH (14-243): 1.02e-62: 200: 46.42
+	Mm
		1206853 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF7_MOUSE (11-105): 2e-26: 105: 40.00
+	Mm
		952211 XPO7_MOUSE (23-1013): 5.43e-120: 397: 13.01		SRSF3_MOUSE (15-99): 9.33e-28: 105: 43.53
+	Dm
		644445 Q9VQG0_DROME (24-1023): 1.78e-89: 309: 12.89		SRR55_DROME (17-183): 2.57e-52: 175: 39.79
+	At
		1208783 MOS14_ARATH (26-1002): 6.38e-104: 350: 13.35		RSZ33_ARATH (15-110): 4.93e-10: 60.5: 45.83