HitPredict

Interactor 1: AT2A1 (O14983)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
Gene: ATP2A1

Interactor 2: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26618866, 17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0034976 - response to endoplasmic reticulum stress
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1001 Hs			1 1480
+	Hs
		528489 AT2A2_HUMAN (1-1000): 0: 950: 83.40		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		529516 AT2A3_HUMAN (1-999): 0: 950: 75.88		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		393007 AT1A1_HUMAN (2-998): 0: 803: 26.10		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528795 AT1A2_HUMAN (2-998): 0: 794: 26.49		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		528564 AT2B4_HUMAN (5-993): 0: 761: 25.05		CFTR_HUMAN (1-1480): 0: 1031: 100.00
+	Hs
		163757 AT2A1_HUMAN (1-1001): 0: 977: 100.00		MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70
+	Dm
		611085 ATC1_DROME (1-990): 0: 907: 71.82		Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95
+	Dm
		530302 ATNA_DROME (3-998): 0: 766: 26.71		Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95