HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: PTC1 (Q13635)
Protein patched homolog 1 (PTC) (PTC1)
Gene: PTCH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001843 - neural tube closure GO:0005886 - plasma membrane GO:0007420 - brain development
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1838 Hs			1 1447
+	Hs
		1044459 PLXA1_HUMAN (12-1831): 0: 2078: 32.31		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		850468 PLXA3_HUMAN (14-1834): 0: 2067: 30.87		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1044473 PLXD1_HUMAN (25-1835): 0: 1862: 32.68		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1044423 SEM3C_HUMAN (24-614): 9.57e-149: 479: 16.30		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1044443 SEM4B_HUMAN (6-595): 3.62e-138: 453: 18.33		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1044436 SEM6A_HUMAN (5-518): 7.22e-131: 438: 18.80		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1027961 SEM3B_HUMAN (5-518): 3.96e-132: 433: 18.61		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		320769 SEM4F_HUMAN (3-576): 3.33e-129: 426: 15.84		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		1044438 SEM6B_HUMAN (22-541): 3.27e-99: 343: 24.22		PTC1_HUMAN (1-1447): 0: 1579: 100.00
+	Hs
		981868 RON_HUMAN (753-1155): 6.05e-73: 272: 22.94		PTC1_HUMAN (1-1447): 0: 1579: 100.00