HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30442762
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 368
+	Hs
		914315 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SH3G1_HUMAN (1-368): 7.32e-90: 276: 100.00
+	Hs
		348654 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		349006 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		350157 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		350683 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		914068 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Hs
		914061 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		914458 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Hs
		349308 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Hs
		348603 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		350048 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		913994 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924750 RAB8B_HUMAN (4-180): 8.57e-74: 222: 36.31		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		349233 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924599 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924749 RAB1C_HUMAN (4-186): 3.44e-72: 218: 32.47		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924763 RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38