HitPredict

Interactor 1: PLXB2 (O15031)
Plexin-B2 (MM1)
Gene: PLXNB2

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PSI~ig, LRR_8~TIG
Common GO terms	GO:0005886 - plasma membrane GO:0010976 - positive regulation of neuron projection development
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1838 Hs			1 839
+	Hs
		165138 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		165144 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		165142 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		165145 PLXB2_HUMAN (1-1838): 0: 2441: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		385553 PLXA4_HUMAN (9-1834): 0: 2124: 32.07		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		441513 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Mm
		555013 MET_MOUSE (687-1228): 1.58e-89: 324: 19.96		NTRK3_MOUSE (1-839): 0: 661: 95.59
+	Hs
		441410 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		441431 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		411279 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435499 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		441498 MET_HUMAN (746-1153): 4.48e-87: 316: 21.38		PTK7_HUMAN (215-380): 9.02e-12: 71.3: 17.34