Protein: PSA4
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)

Gene: PSA4, PSMA4
Organism: Homo sapiens
Interactions: 216
UniProt ID: P25789

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000932 - P-body
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

637626

PSA2
Proteasome subunit alpha type-2

12

20

Small-scale

0.984

High

156226

PSA7
Proteasome subunit alpha type-7

10

19

Small-scale

0.979

High

637318

PSA1
Proteasome subunit alpha type-1

9

18

Small-scale

0.970

High

638179

PSB7
Proteasome subunit beta type-7

7

20

Small-scale

0.963

High

638100

PSA6
Proteasome subunit alpha type-6

6

19

Small-scale

0.943

High

638066

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.922

High

638068

PSB4
Proteasome subunit beta type-4

5

20

Small-scale

0.922

High

638086

PSB2
Proteasome subunit beta type-2

5

20

Small-scale

0.919

High

637766

PSA3
Proteasome subunit alpha type-3

5

20

Small-scale

0.918

High

594450

PSB1
Proteasome subunit beta type-1

4

20

Small-scale

0.903

High

638067

PSA5
Proteasome subunit alpha type-5

4

20

Small-scale

0.900

High

638085

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.861

High

638173

PSMG2
Proteasome assembly chaperone 2

3

10

Small-scale

0.861

High

638065

PSB8
Proteasome subunit beta type-8

3

20

Small-scale

0.847

High

638104

PRS4
26S proteasome regulatory subunit 4

2

20

High-throughput

0.825

High

638132

PSME4
Proteasome activator complex subunit 4

2

8

High-throughput

0.811

High

638220

POMP
Proteasome maturation protein

2

8

Small-scale

0.806

High

121685

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

20

High-throughput

0.806

High

638061

PSA4
Proteasome subunit alpha type-4

2

17

Small-scale

0.806

High

638105

PRS8
26S proteasome regulatory subunit 8

2

20

High-throughput

0.806

High

638116

PSME1
Proteasome activator complex subunit 1

2

19

Small-scale

0.789

High

638069

PSB6
Proteasome subunit beta type-6

2

20

Small-scale

0.754

High

638070

PSB5
Proteasome subunit beta type-5

2

20

Small-scale

0.754

High

638074

PRS7
26S proteasome regulatory subunit 7

2

20

High-throughput

0.754

High

638215

PSME2
Proteasome activator complex subunit 2

2

19

Small-scale

0.754

High

130749

PSDE
26S proteasome non-ATPase regulatory subunit 14

5

20

Small-scale

0.702

High

638078

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.691

High

638224

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

15

Small-scale

0.691

High

226567

PRKN
E3 ubiquitin-protein ligase parkin

4

20

Small-scale

0.690

High

638123

IKZF1
DNA-binding protein Ikaros

3

2

High-throughput

0.675

High

638062

IKBA
NF-kappa-B inhibitor alpha

3

5

Small-scale

0.640

High

638114

UBE3A
Ubiquitin-protein ligase E3A

3

14

Small-scale

0.640

High

638077

HD
Huntingtin

2

3

High-throughput

0.621

High

638093

ATX1
Ataxin-1

2

1

High-throughput

0.621

High

572859

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

638098

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.618

High

638103

PSME3
Proteasome activator complex subunit 3

1

19

Small-scale

0.618

High

638107

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.618

High

345967

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.611

High

638122

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

20

Small-scale

0.611

High

638125

CUL1
Cullin-1

2

6

Small-scale

0.611

High

638139

HIF1A
Hypoxia-inducible factor 1-alpha

2

1

Small-scale

0.611

High

638170

PSMF1
Proteasome inhibitor PI31 subunit

2

8

High-throughput

0.611

High

135009

TRI38
E3 ubiquitin-protein ligase TRIM38

2

4

High-throughput

0.606

High

638113

REL
Proto-oncogene c-Rel

2

4

High-throughput

0.606

High

638195

CARD9
Caspase recruitment domain-containing protein 9

2

3

High-throughput

0.606

High

638076

CCNF
Cyclin-F

2

8

High-throughput

0.601

High

243958

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.584

High

638080

YAP1
Transcriptional coactivator YAP1

2

6

High-throughput

0.584

High

638094

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

8

Small-scale

0.584

High

638097

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

11

High-throughput

0.584

High

638210

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.580

High

92604

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.575

High

638091

PLK1
Serine/threonine-protein kinase PLK1

1

14

Small-scale

0.561

High

638185

PSMG3
Proteasome assembly chaperone 3

2

5

High-throughput

0.558

High

198546

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

9

High-throughput

0.536

High

236882

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

6

High-throughput

0.536

High

314733

PSMG1
Proteasome assembly chaperone 1

1

5

High-throughput

0.536

High

474931

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.536

High

528582

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

638087

PSN1
Presenilin-1

1

3

High-throughput

0.536

High

638090

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.536

High

638108

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

18

High-throughput

0.536

High

638109

SKP1
S-phase kinase-associated protein 1

1

7

High-throughput

0.536

High

638133

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

20

High-throughput

0.536

High

638135

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

9

High-throughput

0.536

High

638184

SLX1
Structure-specific endonuclease subunit SLX1

1

4

High-throughput

0.536

High

638214

AMFR
E3 ubiquitin-protein ligase AMFR

1

9

High-throughput

0.536

High

638219

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

11

High-throughput

0.536

High

638117

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.523

High

128449

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

302371

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

638156

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

171478

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

638110

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

638157

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.501

High

213298

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.500

High

316796

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.500

High

638187

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.500

High

638213

KLF15
Krueppel-like factor 15

1

14

High-throughput

0.500

High

638206

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

121938

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

20

High-throughput

0.479

High

135371

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

5

High-throughput

0.479

High

265116

MAF
Transcription factor Maf

1

5

Small-scale

0.479

High

294391

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

298171

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

302927

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

326447

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

337351

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.479

High

337958

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

373701

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

393045

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.479

High

397788

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

456500

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

15

Small-scale

0.479

High

503469

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

551985

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

570480

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

5

High-throughput

0.479

High

587426

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

Small-scale

0.479

High

638063

U2AF2
Splicing factor U2AF 65 kDa subunit

1

5

High-throughput

0.479

High

638064

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

638071

NOS2
Nitric oxide synthase, inducible

1

4

High-throughput

0.479

High

638072

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

638073

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

638079

MAP1B
Microtubule-associated protein 1B

1

4

High-throughput

0.479

High

638081

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

638082

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

638083

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

638088

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.479

High

638089

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

20

High-throughput

0.479

High

638092

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

638095

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

638096

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

638101

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

638102

ARP2
Actin-related protein 2

1

1

High-throughput

0.479

High

638106

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

638111

RELB
Transcription factor RelB

1

4

High-throughput

0.479

High

638115

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

High-throughput

0.479

High

638119

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

638120

NFX1
Transcriptional repressor NF-X1

1

6

High-throughput

0.479

High

638121

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

Small-scale

0.479

High

638124

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

638126

PTC1
Protein patched homolog 1

1

4

Small-scale

0.479

High

638127

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

5

Small-scale

0.479

High

638129

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

638130

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

638134

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

7

Small-scale

0.479

High

638136

NEDD8
NEDD8

1

12

Small-scale

0.479

High

638137

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

638138

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

10

High-throughput

0.479

High

638140

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

638141

LARP7
La-related protein 7

1

6

High-throughput

0.479

High

638142

MIDN
Midnolin

1

4

High-throughput

0.479

High

638143

AKIR2
Akirin-2

1

6

Small-scale

0.479

High

638146

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

638148

ECM29
Proteasome adapter and scaffold protein ECM29

1

10

High-throughput

0.479

High

638149

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

638150

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

638151

DESI1
Desumoylating isopeptidase 1

1

5

Small-scale

0.479

High

638153

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

638154

SEML
Putative protein SEM1, isoform 2

1

2

High-throughput

0.479

High

638155

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

638158

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

638159

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

638160

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

638161

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

638162

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

638163

GOLI
E3 ubiquitin-protein ligase RNF130

1

16

High-throughput

0.479

High

638164

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.479

High

638165

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

638166

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

638171

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

15

High-throughput

0.479

High

638172

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

638174

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

638176

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

638177

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

4

Small-scale

0.479

High

638180

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

638181

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

4

High-throughput

0.479

High

638182

TBX5
T-box transcription factor TBX5

1

1

High-throughput

0.479

High

638183

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

638188

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

8

Small-scale

0.479

High

638189

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

638190

BHE41
Class E basic helix-loop-helix protein 41

1

2

Small-scale

0.479

High

638192

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

638194

SHRPN
Sharpin

1

5

Small-scale

0.479

High

638196

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.479

High

638198

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.479

High

638199

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.479

High

638200

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.479

High

638201

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

High-throughput

0.479

High

638202

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

638203

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

638204

UBQL4
Ubiquilin-4

1

20

Small-scale

0.479

High

638205

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

638208

PD1L1
Programmed cell death 1 ligand 1

1

2

Small-scale

0.479

High

638209

CHMP5
Charged multivesicular body protein 5

1

4

High-throughput

0.479

High

638211

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

638212

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

638216

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

638217

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

638218

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

638222

FBX7
F-box only protein 7

1

4

High-throughput

0.479

High

638223

TRAF6
TNF receptor-associated factor 6

1

7

High-throughput

0.479

High

122503

MEN1
Menin

1

0

High-throughput

0.458

High

241975

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

536309

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.458

High

554406

GATA1
Erythroid transcription factor

1

0

High-throughput

0.458

High

638075

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

638099

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

638112

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

638118

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

638167

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

638169

ASB10
Ankyrin repeat and SOCS box protein 10

1

0

Small-scale

0.458

High

638178

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

638193

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

638197

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

688

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.445

High

401444

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

496339

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

581441

VCAM1
Vascular cell adhesion protein 1

1

3

High-throughput

0.445

High

638145

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

638147

Q5VWC4
26S proteasome non-ATPase regulatory subunit 4

1

11

High-throughput

0.445

High

329376

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

384294

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

638128

GRM2
Metabotropic glutamate receptor 2

1

5

High-throughput

0.437

High

638144

PSMG4
Proteasome assembly chaperone 4

1

4

High-throughput

0.437

High

638168

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

638175

RN185
E3 ubiquitin-protein ligase RNF185

1

16

Small-scale

0.437

High

638191

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.437

High

638207

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

638221

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

638225

INSI2
Insulin-induced gene 2 protein

1

3

High-throughput

0.437

High

638152

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

638084

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

638131

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

638186

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024