HitPredict

Interactor 1: SET1A (O15047)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)
Gene: SETD1A

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22266653
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1707 Hs			1 136
+	Hs
		165661 SET1A_HUMAN (1-1707): 6.31e-168: 556: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Mm
		93307 SET1A_MOUSE (1-1707): 3.49e-167: 554: 86.72		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		935276 ASH1L_HUMAN (140-1706): 1.39e-88: 324: 11.66		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		952649 ASH1L_HUMAN (140-1706): 1.39e-88: 324: 11.66		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Dm
		356118 ASH1_DROME (871-1706): 3.35e-75: 280: 16.38		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		935368 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1174689 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Hs
		952698 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		952754 Q6AXH7_MOUSE (1163-1690): 2.64e-76: 272: 14.81		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		934804 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Sp
		457194 SET1_SCHPO (1173-1707): 7.33e-76: 275: 27.60		H31_SCHPO (1-136): 2.22e-59: 181: 91.91
+	Hs
		1079993 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Mm
		952747 EZH2_MOUSE (1163-1690): 2.57e-75: 269: 14.95		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		952363 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		934681 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1080038 EZH2_HUMAN (1161-1690): 6.02e-75: 268: 14.71		H3C_HUMAN (1-136): 8.83e-59: 179: 94.12
+	Mm
		139069 KMT2B_MOUSE (882-1707): 2.62e-69: 261: 20.88		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Sc
		755791 SET1_YEAST (1286-1707): 1.12e-70: 261: 27.36		H3_YEAST (1-136): 7.77e-56: 172: 88.97
+	Hs
		828421 KMT2B_HUMAN (1010-1707): 4.16e-74: 277: 22.55		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Hs
		828202 KMT2A_HUMAN (1094-1707): 3.48e-69: 261: 21.28		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00