HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35332268
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 426 Hs			1 1050
+	Hs
		167384 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Mm
		192495 SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12		SMUF1_MOUSE (557-1047): 1.9e-175: 532: 23.96
+	Hs
		125003 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		167393 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		167395 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91
+	Mm
		56823 SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12		SMUF2_MOUSE (557-1047): 1.28e-170: 520: 23.66
+	Hs
		167342 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		167385 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		167394 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		SMUF2_HUMAN (557-1047): 1.53e-170: 519: 23.66
+	Hs
		206970 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		ITCH_HUMAN (604-1048): 8.2e-178: 544: 26.60
+	Hs
		125023 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		WWP2_HUMAN (573-1048): 1.25e-175: 537: 23.06
+	Hs
		206975 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Dm
		785516 MAD_DROME (72-424): 2.77e-151: 438: 25.48		SUDX_DROME (604-1047): 2.1e-168: 521: 23.37
+	Hs
		1305881 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		WWP1_HUMAN (605-1048): 6.26e-173: 532: 24.09
+	Hs
		206977 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		SMUF1_HUMAN (596-1047): 4.57e-174: 529: 25.91
+	Hs
		206944 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		206971 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		NED4L_HUMAN (606-1048): 2.42e-169: 524: 25.21
+	Hs
		808240 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		NEDD4_HUMAN (604-1048): 8.67e-167: 527: 24.22
+	Hs
		206976 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		SMUF2_HUMAN (557-1047): 1.53e-170: 519: 23.66
+	Dm
		785477 MAD_DROME (72-424): 2.77e-151: 438: 25.48		SMUF1_DROME (690-1049): 3.21e-153: 484: 30.40