HitPredict

Interactor 1: RPAC1 (O15160)
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)
Gene: POLR1C

Interactor 2: RPB1C (Q9H1A7)
DNA-directed RNA polymerase II subunit RPB11-b2 (RNA polymerase II subunit B11-b2) (RPB11b2) (DNA-directed RNA polymerase II subunit J3)
Gene: POLR2J3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RNA_pol_L~RNA_pol_L_2
Common GO terms	GO:0003677 - DNA binding GO:0046983 - protein dimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 115
+	Hs
		169941 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPB1B_HUMAN (1-115): 9.44e-52: 160: 99.13
+	Hs
		169818 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPB11_HUMAN (1-108): 4.58e-46: 146: 95.41
+	Hs
		169778 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPAC2_HUMAN (29-108): 2.52e-34: 117: 32.50
+	Sp
		293857 RPAC1_SCHPO (6-346): 6.06e-150: 427: 49.71		RPAC2_SCHPO (24-108): 1.17e-32: 112: 36.47
+	Sc
		429651 RPAC1_YEAST (10-338): 1.98e-143: 410: 44.88		RPAC2_YEAST (14-108): 5.11e-34: 116: 31.58
+	Dm
		1368240 Q9VMX3_DROME (30-343): 7.43e-139: 399: 53.97		RPAC2_DROME (31-108): 1.13e-27: 99.3: 30.77
+	Hs
		583571 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPB1B_HUMAN (1-115): 9.44e-52: 160: 99.13
+	At
		1104914 NRPB3_ARATH (41-346): 6.05e-109: 322: 29.15		NRPBB_ARATH (1-108): 1.91e-45: 144: 48.62
+	At
		1104915 RPD3B_ARATH (41-346): 1.4e-106: 316: 29.47		NRPBB_ARATH (1-108): 1.91e-45: 144: 48.62
+	Hs
		583438 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPB11_HUMAN (1-108): 4.58e-46: 146: 95.41
+	Mm
		956874 RPB3_MOUSE (45-346): 3.26e-105: 311: 26.71		Q3TYI2_MOUSE (1-108): 3.01e-45: 143: 94.50
+	Dm
		333012 O97183_DROME (45-346): 3.36e-105: 311: 22.95		RPB11_DROME (1-108): 2.72e-44: 141: 76.15
+	Sc
		558050 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPB11_YEAST (1-107): 8.12e-42: 135: 51.85
+	Sc
		557923 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPAC2_YEAST (14-108): 5.11e-34: 116: 31.58
+	Sp
		741615 RPB3_SCHPO (50-344): 8.21e-89: 270: 24.50		RPB11_SCHPO (1-104): 4.78e-38: 125: 48.08
+	Ss
		955989 RPO3_SACS2 (50-343): 4.62e-79: 244: 28.09		RPO11_SACS2 (18-105): 1.34e-25: 93.5: 32.96
+	Mj
		1123053 RPO3_METJA (51-266): 1.23e-52: 174: 26.94		RPO11_METJA (18-107): 8.38e-19: 76.6: 24.49