HitPredict

Interactor 1: EPHB6 (O15197)
Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)
Gene: EPHB6

Interactor 2: TRI18 (O15344)
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
Gene: MID1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ephrin_lbd~fn3, fn3~fn3, PK_Tyr_Ser-Thr~fn3
Common GO terms	GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1021 Hs			1 667
+	Hs
		665616 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		665406 EPHA3_HUMAN (30-1021): 0: 1092: 38.87		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		665655 EPHB2_HUMAN (33-1020): 0: 1130: 45.97		TRI54_HUMAN (1-380): 7.45e-80: 259: 22.80
+	Hs
		872407 EPHB3_HUMAN (28-1021): 0: 1080: 45.25		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		872543 EPHB4_HUMAN (21-1014): 0: 998: 40.97		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		665273 EPHA2_HUMAN (31-1017): 0: 988: 37.41		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Hs
		171336 EPHB6_HUMAN (1-1021): 0: 1080: 100.00		TRI39_HUMAN (1-396): 3.99e-23: 105: 15.40
+	Hs
		242813 EPHA8_HUMAN (33-1018): 0: 1017: 38.36		TRI13_HUMAN (1-97): 1.22e-14: 78.2: 40.21
+	Hs
		674465 UFO_HUMAN (269-967): 9.15e-152: 475: 22.05		TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39
+	Rn
		69936 INSR_RAT (434-949): 5.4e-136: 445: 26.37		B1H2A2_RAT (216-666): 1.51e-87: 284: 27.35
+	Rn
		71346 INSR_RAT (434-949): 5.4e-136: 445: 26.37		B2RYH2_RAT (159-653): 8.86e-74: 246: 15.94
+	Rn
		88528 INSR_RAT (434-949): 5.4e-136: 445: 26.37		D3ZBI1_RAT (478-650): 3.31e-16: 82.8: 31.15
+	Hs
		242800 INSR_HUMAN (421-949): 1.03e-135: 444: 25.76		TRI13_HUMAN (1-97): 1.22e-14: 78.2: 40.21
+	Hs
		435641 IGF1R_HUMAN (385-555): 3.28e-11: 69.7: 22.41		TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80
+	Hs
		242801 IGF1R_HUMAN (385-555): 3.28e-11: 69.7: 22.41		TRI13_HUMAN (1-97): 1.22e-14: 78.2: 40.21