HitPredict

Interactor 1: EPHB6 (O15197)
Ephrin type-B receptor 6 (HEP) (Tyrosine-protein kinase-defective receptor EPH-6)
Gene: EPHB6

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35384245, 22939624
Identification Methods	proximity labelling technology, affinity chromatography technology, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1021 Hs			1 724
+	Hs
		438028 EPHB1_HUMAN (32-1016): 0: 1119: 46.71		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431691 EPHB1_HUMAN (32-1016): 0: 1119: 46.71		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438029 EPHA4_HUMAN (14-1021): 0: 1097: 39.38		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431692 EPHA4_HUMAN (14-1021): 0: 1097: 39.38		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431562 EPHA3_HUMAN (30-1021): 0: 1092: 38.87		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		171280 EPHB6_HUMAN (1-1021): 0: 1080: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437918 EPHA2_HUMAN (31-1017): 0: 988: 37.41		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431561 EPHA2_HUMAN (31-1017): 0: 988: 37.41		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437892 EPHA1_HUMAN (25-1010): 0: 918: 36.59		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431531 EPHA1_HUMAN (25-1010): 0: 918: 36.59		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538261 EPHAA_HUMAN (16-1017): 0: 933: 36.54		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		437923 UFO_HUMAN (269-967): 9.15e-152: 475: 22.05		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438114 MERTK_HUMAN (269-953): 8.21e-146: 462: 19.22		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431568 UFO_HUMAN (269-967): 9.15e-152: 475: 22.05		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431788 MERTK_HUMAN (269-953): 8.21e-146: 462: 19.22		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438100 TYRO3_HUMAN (270-999): 4.34e-140: 444: 20.82		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431770 TYRO3_HUMAN (270-999): 4.34e-140: 444: 20.82		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538120 UFO_HUMAN (269-967): 9.15e-152: 475: 22.05		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Rn
		544887 INSR_RAT (434-949): 5.4e-136: 445: 26.37		ENPL_RAT (3-695): 0: 921: 45.74
+	Hs
		674450 UFO_HUMAN (269-967): 9.15e-152: 475: 22.05		H90B3_HUMAN (1-724): 0: 815: 75.83