HitPredict

Interactor 1: SMAD9 (O15198)
Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9)
Gene: SMAD9

Interactor 2: TRIPC (Q14669)
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)
Gene: TRIP12

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 1992
+	Hs
		1305892 SMAD5_HUMAN (4-467): 0: 631: 78.37		HECW2_HUMAN (924-1991): 0: 626: 14.87
+	Hs
		1078757 SMAD1_HUMAN (7-467): 0: 641: 80.86		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		1305881 SMAD5_HUMAN (4-467): 0: 631: 78.37		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Dm
		785516 MAD_DROME (3-467): 0: 622: 71.83		SUDX_DROME (1349-1989): 0: 583: 20.46
+	Hs
		125369 SMAD3_HUMAN (7-467): 0: 580: 58.19		WWP2_HUMAN (1053-1990): 0: 603: 18.31
+	Hs
		1078760 SMAD1_HUMAN (7-467): 0: 641: 80.86		SMUF2_HUMAN (1373-1989): 2.4e-168: 535: 19.18
+	Mm
		56826 SMAD1_MOUSE (7-467): 0: 643: 80.86		SMUF2_MOUSE (1373-1989): 7.28e-168: 533: 19.33
+	Hs
		950248 SMAD3_HUMAN (7-467): 0: 580: 58.19		ITCH_HUMAN (1018-1990): 0: 591: 17.29
+	Hs
		808135 SMAD1_HUMAN (7-467): 0: 641: 80.86		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		950249 SMAD3_HUMAN (7-467): 0: 580: 58.19		NED4L_HUMAN (989-1990): 0: 588: 16.37
+	Mm
		936618 SMAD1_MOUSE (7-467): 0: 643: 80.86		SMUF1_MOUSE (1441-1989): 1.06e-164: 524: 19.18
+	Hs
		1305886 SMAD5_HUMAN (4-467): 0: 631: 78.37		SMUF2_HUMAN (1373-1989): 2.4e-168: 535: 19.18
+	Hs
		950278 SMAD3_HUMAN (7-467): 0: 580: 58.19		WWP1_HUMAN (1038-1990): 0: 580: 16.88
+	Hs
		808240 SMAD5_HUMAN (4-467): 0: 631: 78.37		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Xl
		945613 P79947_XENLA (7-467): 0: 646: 80.60		SMUF1_XENLA (1481-1989): 1.21e-159: 510: 20.18
+	Hs
		1078761 SMAD1_HUMAN (7-467): 0: 641: 80.86		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46
+	Hs
		1305888 SMAD5_HUMAN (4-467): 0: 631: 78.37		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46
+	Hs
		950287 SMAD3_HUMAN (7-467): 0: 580: 58.19		SMUF2_HUMAN (1373-1989): 2.4e-168: 535: 19.18
+	Hs
		808087 SMAD3_HUMAN (7-467): 0: 580: 58.19		NEDD4_HUMAN (814-1990): 2.08e-159: 528: 13.49
+	Hs
		950291 SMAD3_HUMAN (7-467): 0: 580: 58.19		SMUF1_HUMAN (1455-1989): 1.22e-158: 508: 18.46