HitPredict

Interactor 1: RGL2 (O15211)
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
Gene: RGL2

Interactor 2: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.744

Property	Details
Experiments	21988832, 34591642
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 189
+	Hs
		171533 RGL2_HUMAN (11-777): 0: 804: 100.00		RASK_HUMAN (16-189): 7.56e-85: 249: 85.71
+	Mm
		699619 RGL2_MOUSE (11-777): 0: 800: 89.58		RASK_MOUSE (1-189): 3.25e-85: 251: 87.90
+	Mm
		440302 RGL2_MOUSE (11-777): 0: 800: 89.58		RASN_MOUSE (1-189): 5.14e-80: 237: 98.41
+	Hs
		171532 RGL2_HUMAN (11-777): 0: 804: 100.00		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Hs
		171541 RGL2_HUMAN (11-777): 0: 804: 100.00		RAP1B_HUMAN (1-165): 1.02e-61: 191: 56.89
+	Hs
		171535 RGL2_HUMAN (11-777): 0: 804: 100.00		RALA_HUMAN (4-169): 7.15e-59: 184: 53.89
+	Hs
		348971 RGL1_HUMAN (49-760): 0: 581: 32.27		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		349692 RGL1_HUMAN (49-760): 0: 581: 32.27		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Mm
		1113379 RGL3_MOUSE (43-745): 0: 553: 34.53		RASH_MOUSE (1-188): 8.6e-78: 232: 85.64
+	Hs
		897964 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1B_HUMAN (1-165): 1.02e-61: 191: 56.89
+	Hs
		919681 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1A_HUMAN (1-165): 1.22e-60: 188: 56.29
+	Hs
		348697 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASN_HUMAN (1-189): 9.9e-80: 236: 100.00
+	Hs
		1273185 RGL1_HUMAN (49-760): 0: 581: 32.27		RIT1_HUMAN (3-165): 2.73e-56: 178: 52.44
+	Hs
		349360 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Dm
		442998 Q86BI2_DROME (45-739): 3.76e-162: 490: 28.18		RAS1_DROME (1-170): 2.87e-90: 263: 83.53
+	Hs
		349455 GRP3_HUMAN (93-768): 3.48e-171: 511: 18.91		RASH_HUMAN (1-188): 8.6e-78: 232: 85.64
+	Mm
		936775 RGL3_MOUSE (43-745): 0: 553: 34.53		RIT1_MOUSE (3-165): 7.07e-57: 180: 52.44
+	Mm
		1113380 RGL3_MOUSE (43-745): 0: 553: 34.53		RALB_MOUSE (4-170): 1.95e-55: 176: 52.07
+	Hs
		1109718 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RIT1_HUMAN (3-165): 2.73e-56: 178: 52.44
+	Dm
		442959 Q86BI2_DROME (45-739): 3.76e-162: 490: 28.18		RAP1_DROME (1-163): 7.92e-63: 194: 59.15