Protein: RN139
E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)

Gene: RN139, RNF139
Organism: Homo sapiens
Interactions: 49
UniProt ID: Q8WU17

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

970830

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1218734

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1356233

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1356232

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

3

Small-scale

0.665

High

192504

INSI1
Insulin-induced gene 1 protein

3

5

Small-scale

0.640

High

952451

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.618

High

1356223

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

19

High-throughput

0.618

High

1350114

SPP
Signal peptide peptidase

2

1

Small-scale

0.612

High

564118

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

321316

ERLN2
Erlin-2

1

9

Small-scale

0.515

High

1356226

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1121830

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

7

Small-scale

0.501

High

350333

LY66D
Lymphocyte antigen 6 complex locus protein G6d

1

1

High-throughput

0.489

High

171527

S27A2
Long-chain fatty acid transport protein 2

1

4

High-throughput

0.479

High

283319

ERLN1
Erlin-1

1

7

Small-scale

0.479

High

338518

SC24B
Protein transport protein Sec24B

1

4

Small-scale

0.479

High

350252

FADS2
Acyl-CoA 6-desaturase

1

2

High-throughput

0.479

High

399718

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

11

Small-scale

0.479

High

520940

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

Small-scale

0.479

High

608981

XBP1
X-box-binding protein 1

1

3

Small-scale

0.479

High

617331

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

5

High-throughput

0.479

High

640965

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

2

High-throughput

0.479

High

1085352

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

10

Small-scale

0.479

High

1085451

SRBP2
Sterol regulatory element-binding protein 2

1

1

Small-scale

0.479

High

1218440

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.479

High

1356224

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

1356225

CCD47
PAT complex subunit CCDC47

1

3

High-throughput

0.479

High

1356227

CLP1L
Lipid scramblase CLPTM1L

1

1

High-throughput

0.479

High

1356229

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

4

High-throughput

0.479

High

1356230

RNF5
E3 ubiquitin-protein ligase RNF5

1

10

High-throughput

0.479

High

1356235

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1356236

INSI2
Insulin-induced gene 2 protein

1

5

Small-scale

0.479

High

1356237

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

3

Small-scale

0.479

High

450259

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.458

High

613109

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

822780

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

1271356

ABHDD
Protein ABHD13

1

0

High-throughput

0.458

High

1315458

K2013
Uncharacterized protein KIAA2013

1

0

High-throughput

0.458

High

1356228

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

High-throughput

0.458

High

1356231

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.458

High

256094

S19A2
Thiamine transporter 1

1

1

High-throughput

0.445

High

1236244

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.445

High

460853

CATB
Cathepsin B

1

1

High-throughput

0.437

High

722733

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

1

High-throughput

0.437

High

1086473

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

1

2

Small-scale

0.437

High

1356234

TM165
Putative divalent cation/proton antiporter TMEM165

1

2

High-throughput

0.437

High

1246092

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

3

High-throughput

0.407

High

1337880

ZNT7
Zinc transporter 7

1

9

High-throughput

0.407

High

927446

ATX1
Ataxin-1

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025