Protein: ZNRF4
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)

Gene: ZNRF4
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q8WWF5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987427

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

8

High-throughput

0.811

High

1359371

AMFR
E3 ubiquitin-protein ligase AMFR

2

14

High-throughput

0.811

High

906721

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

909360

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

952452

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

957147

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

957801

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

982262

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1359343

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1359375

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1103567

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

3

1

High-throughput

0.667

High

1207884

S27A3
Long-chain fatty acid transport protein 3

3

6

High-throughput

0.667

High

1313211

PLPL6
Patatin-like phospholipase domain-containing protein 6

3

0

High-throughput

0.638

High

1359344

ASTRA
Protein Aster-A

3

0

High-throughput

0.638

High

175475

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

2

6

High-throughput

0.628

High

247530

FZD6
Frizzled-6

2

6

High-throughput

0.628

High

282609

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

2

3

High-throughput

0.628

High

321012

SUN1
SUN domain-containing protein 1

2

1

High-throughput

0.628

High

325574

YIF1A
Protein YIF1A

2

1

High-throughput

0.628

High

337784

SGPL1
Sphingosine-1-phosphate lyase 1

2

1

High-throughput

0.628

High

643382

OSBP1
Oxysterol-binding protein 1

2

3

High-throughput

0.628

High

1085357

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

2

12

High-throughput

0.628

High

1085453

SRBP2
Sterol regulatory element-binding protein 2

2

1

High-throughput

0.628

High

1091958

SEC20
Vesicle transport protein SEC20

2

1

High-throughput

0.628

High

1128354

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

2

1

High-throughput

0.628

High

1294470

VRK2
Serine/threonine-protein kinase VRK2

2

6

High-throughput

0.628

High

1337610

PDZD8
PDZ domain-containing protein 8

2

1

High-throughput

0.628

High

1353395

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

2

11

High-throughput

0.628

High

1359346

P121A
Nuclear envelope pore membrane protein POM 121

2

7

High-throughput

0.628

High

1359353

NDC1
Nucleoporin NDC1

2

3

High-throughput

0.628

High

1359356

OSBL8
Oxysterol-binding protein-related protein 8

2

3

High-throughput

0.628

High

1359358

DJC18
DnaJ homolog subfamily C member 18

2

9

High-throughput

0.628

High

1359362

ZDH18
Palmitoyltransferase ZDHHC18

2

6

High-throughput

0.628

High

1359368

NB5R1
NADH-cytochrome b5 reductase 1

2

4

High-throughput

0.628

High

1359373

S27A6
Long-chain fatty acid transport protein 6

2

6

High-throughput

0.628

High

1359376

TMX2
Thioredoxin-related transmembrane protein 2

2

2

High-throughput

0.628

High

1359377

ZDHC9
Palmitoyltransferase ZDHHC9

2

6

High-throughput

0.628

High

1359342

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.625

High

1356223

RN139
E3 ubiquitin-protein ligase RNF139

1

19

High-throughput

0.618

High

1218443

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

2

4

High-throughput

0.611

High

639391

5NTD
5'-nucleotidase

2

2

High-throughput

0.606

High

155488

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.602

High

261234

NSMA
Sphingomyelin phosphodiesterase 2

2

0

High-throughput

0.602

High

790166

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

2

0

High-throughput

0.602

High

1127846

ERG1
Squalene monooxygenase

2

0

High-throughput

0.602

High

1293789

FBX11
F-box only protein 11

2

0

High-throughput

0.602

High

1359349

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.602

High

1359378

DGLA
Diacylglycerol lipase-alpha

2

0

High-throughput

0.602

High

72671

UPK3L
Uroplakin-3b-like protein 1

2

1

High-throughput

0.574

High

213334

ADCY6
Adenylate cyclase type 6

2

2

High-throughput

0.574

High

1195365

ANO6
Anoctamin-6

2

1

High-throughput

0.574

High

1248251

KCNT2
Potassium channel subfamily T member 2

2

3

High-throughput

0.574

High

1351777

ST7L
Suppressor of tumorigenicity 7 protein-like

2

1

High-throughput

0.574

High

1358611

BT2A2
Butyrophilin subfamily 2 member A2

2

6

High-throughput

0.574

High

1359341

PTPRU
Receptor-type tyrosine-protein phosphatase U

2

6

High-throughput

0.574

High

1359351

ABCA3
Phospholipid-transporting ATPase ABCA3

2

3

High-throughput

0.574

High

1359355

ABCA2
ATP-binding cassette sub-family A member 2

2

2

High-throughput

0.574

High

1359357

PCX3
Pecanex-like protein 3

2

2

High-throughput

0.574

High

1359364

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

2

3

High-throughput

0.574

High

1359367

SUN2
SUN domain-containing protein 2

2

1

High-throughput

0.574

High

1359369

S12A6
Solute carrier family 12 member 6

2

7

High-throughput

0.574

High

1359370

KCNG1
Voltage-gated potassium channel regulatory subunit KCNG1

2

2

High-throughput

0.574

High

1359372

VANG2
Vang-like protein 2

2

2

High-throughput

0.574

High

1359374

MAN1
Inner nuclear membrane protein Man1

2

4

High-throughput

0.574

High

1359379

LRP12
Low-density lipoprotein receptor-related protein 12

2

3

High-throughput

0.574

High

1359380

SNX14
Sorting nexin-14

2

4

High-throughput

0.574

High

1359381

S12A7
Solute carrier family 12 member 7

2

5

High-throughput

0.574

High

214452

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.561

High

1330654

TPRX1
Tetra-peptide repeat homeobox protein 1

2

2

High-throughput

0.553

High

1116829

AVR2B
Activin receptor type-2B

1

11

High-throughput

0.536

High

1128442

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

High-throughput

0.536

High

1359360

AT132
Polyamine-transporting ATPase 13A2

1

9

High-throughput

0.536

High

1211076

PR15B
Protein phosphatase 1 regulatory subunit 15B

2

0

High-throughput

0.528

High

1359345

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.513

High

1359347

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.513

High

1359363

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.513

High

386029

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.489

High

1247611

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.489

High

1270276

BT2A1
Butyrophilin subfamily 2 member A1

1

6

High-throughput

0.489

High

1359361

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

124420

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

171531

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.479

High

274683

DNJB6
DnaJ homolog subfamily B member 6

1

7

High-throughput

0.479

High

399720

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

11

High-throughput

0.479

High

450261

HYEP
Epoxide hydrolase 1

1

1

High-throughput

0.479

High

535340

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

698947

CALX
Calnexin

1

5

Small-scale

0.479

High

911996

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.479

High

1359348

SDF2
Stromal cell-derived factor 2

1

6

High-throughput

0.479

High

1359350

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

High-throughput

0.479

High

1359352

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

5

High-throughput

0.479

High

1359359

SDF2L
Stromal cell-derived factor 2-like protein 1

1

6

High-throughput

0.479

High

1359366

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.479

High

1153567

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1359365

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.458

High

126155

AP3B1
AP-3 complex subunit beta-1

1

8

High-throughput

0.437

High

460854

CATB
Cathepsin B

1

2

High-throughput

0.437

High

722735

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.437

High

1143762

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.437

High

1155591

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1315460

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.437

High

321776

AGRL1
Adhesion G protein-coupled receptor L1

2

0

High-throughput

0.328

High

1010506

EREP3
Protein ENTREP3

2

0

High-throughput

0.328

High

1217651

MARC1
Mitochondrial amidoxime-reducing component 1

2

0

High-throughput

0.328

High

1279529

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

2

0

High-throughput

0.328

High

1335211

NETO2
Neuropilin and tolloid-like protein 2

2

0

High-throughput

0.328

High

1359354

CA043
Protein C1orf43

2

0

High-throughput

0.328

High

139280

UPK2
Uroplakin-2

2

0

High-throughput

0.316

High

877365

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025