HitPredict

Interactor 1: SPTC1 (O15269)
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)
Gene: SPTLC1

Interactor 2: SPTC2 (O15270)
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)
Gene: SPTLC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.783

The method score is based on:

Property Details
Experiments 35271311, 19416851
Identification Methods affinity chromatography technology, ubiquitin reconstruction, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Aminotran_1_2~Aminotran_1_2
Common GO terms GO:0004758 - serine C-palmitoyltransferase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0006686 - sphingomyelin biosynthetic process
GO:0017059 - serine palmitoyltransferase complex
GO:0030148 - sphingolipid biosynthetic process
and 5 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 473
Hs

1 562
+ Hs
+ Mm
+ Dm
+ Hs
+ At
+ Sc
+ Sc
+ Ec
+ Sc
+ Ec

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024