HitPredict

Interactor 1: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

The method score is based on:

Property	Details
Experiments	19442657, 25893286, 10391251, 10391250, 11278685
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	P53~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006298 - mismatch repair GO:0006974 - DNA damage response and 5 others more... GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0009410 - response to xenobiotic stimulus GO:0043065 - positive regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051726 - regulation of cell cycle
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	636
Hs

1	1130

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024