Protein: UFD4
Ubiquitin fusion degradation protein 4 (UB fusion protein 4) (EC 2.3.2.-) (HECT-type E3 ubiquitin transferase UFD4) (EC 2.3.2.26)

Gene: UFD4
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: P33202

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585695

UBC4
Ubiquitin-conjugating enzyme E2 4

5

20

Small-scale

0.924

High

509468

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

4

20

Small-scale

0.885

High

750203

PRS8
26S proteasome regulatory subunit 8 homolog

3

20

Small-scale

0.681

High

750180

UFD4
Ubiquitin fusion degradation protein 4

1

15

Small-scale

0.621

High

509886

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

20

High-throughput

0.618

High

750204

UBC7
Ubiquitin-conjugating enzyme E2 7

1

20

Small-scale

0.618

High

684063

MGMT
Methylated-DNA--protein-cysteine methyltransferase

2

0

Small-scale

0.612

High

625951

UBR1
E3 ubiquitin-protein ligase UBR1

2

0

Small-scale

0.606

High

750193

TCPQ
T-complex protein 1 subunit theta

2

16

High-throughput

0.601

High

750181

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

526279

HSP72
Heat shock protein SSA2

2

14

High-throughput

0.552

High

544305

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.552

High

619342

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

12

High-throughput

0.541

High

358992

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.536

High

386649

TBB
Tubulin beta chain

1

16

High-throughput

0.536

High

394403

EF1A
Elongation factor 1-alpha

1

9

High-throughput

0.536

High

453509

PYR1
Multifunctional protein URA2

1

12

High-throughput

0.536

High

486114

TBA1
Tubulin alpha-1 chain

1

14

High-throughput

0.536

High

518246

IF4A
ATP-dependent RNA helicase eIF4A

1

20

High-throughput

0.536

High

750185

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.536

High

750192

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

750195

FMP48
Probable serine/threonine-protein kinase FMP48

1

17

High-throughput

0.536

High

750217

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.536

High

622347

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.515

High

750186

RPN1
26S proteasome regulatory subunit RPN1

1

12

Small-scale

0.515

High

677797

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.513

High

739120

PRP19
Pre-mRNA-processing factor 19

1

16

High-throughput

0.508

High

750196

PRS10
26S proteasome subunit RPT4

1

20

Small-scale

0.501

High

750198

UFD2
E4 ubiquitin-protein ligase UFD2

1

3

Small-scale

0.501

High

750211

TPO1
Polyamine transporter 1

1

2

High-throughput

0.494

High

747258

RSSA1
Small ribosomal subunit protein uS2A

1

9

High-throughput

0.489

High

750188

TEM1
Protein TEM1

1

7

High-throughput

0.489

High

750201

AP1M1
AP-1 complex subunit mu-1-I

1

4

High-throughput

0.489

High

750200

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

4

High-throughput

0.481

High

430819

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

11

Small-scale

0.479

High

603030

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

649592

KCC2
Calcium/calmodulin-dependent protein kinase II

1

6

High-throughput

0.479

High

706635

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

740844

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

11

High-throughput

0.479

High

747775

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

750183

SPT21
Protein SPT21

1

1

High-throughput

0.479

High

750184

ATG8
Autophagy-related protein 8

1

13

High-throughput

0.479

High

750191

PSA4
Proteasome subunit alpha type-4

1

20

Small-scale

0.479

High

750199

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

20

Small-scale

0.479

High

750205

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

750206

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.479

High

750210

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

750213

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

750214

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

750189

ATC3
Phospholipid-transporting ATPase DRS2

1

4

High-throughput

0.470

High

750202

KIN4
Serine/threonine-protein kinase KIN4

1

19

High-throughput

0.470

High

734910

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

750208

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

427200

RLA0
Large ribosomal subunit protein uL10

1

5

High-throughput

0.445

High

456374

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.445

High

523478

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

579110

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.445

High

590588

HSP26
Heat shock protein 26

1

9

High-throughput

0.445

High

592137

VATB
V-type proton ATPase subunit B

1

10

High-throughput

0.445

High

670522

SIS1
Protein SIS1

1

14

High-throughput

0.445

High

675856

MAS5
Mitochondrial protein import protein MAS5

1

12

High-throughput

0.445

High

741260

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

750182

MDJ1
DnaJ homolog 1, mitochondrial

1

12

High-throughput

0.445

High

750187

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.445

High

750190

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

750207

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

19

High-throughput

0.445

High

750215

HSP42
Heat shock protein 42

1

9

High-throughput

0.445

High

682224

SPB4
ATP-dependent rRNA helicase SPB4

1

20

High-throughput

0.437

High

750209

YD073
UPF0592 protein YDL073W

1

1

High-throughput

0.437

High

750197

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

750212

AB140
tRNA(Thr)

1

0

High-throughput

0.426

High

750216

JID1
J domain-containing protein 1

1

0

High-throughput

0.426

High

613848

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.407

High

750194

HLJ1
Protein HLJ1

1

12

High-throughput

0.407

High

737194

HYM1
Protein HYM1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025