HitPredict

Interactor 1: HDAC3 (O15379)
Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)
Gene: HDAC3

Interactor 2: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	33961781, 12502735, 23752268
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 428 Hs			1 541
+	Hs
		821200 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPE_HUMAN (1-541): 0: 635: 100.00
+	Hs
		821342 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPE_HUMAN (1-541): 0: 635: 100.00
+	Hs
		177233 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		177367 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		826651 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		1038670 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPH_HUMAN (12-539): 0: 570: 29.64
+	Hs
		826803 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPG_HUMAN (14-540): 0: 572: 33.15
+	Hs
		177188 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		573251 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Hs
		573401 HDAC2_HUMAN (3-422): 0: 580: 58.63		TCPA_HUMAN (26-541): 0: 545: 32.08
+	Sc
		693029 RPD3_YEAST (3-414): 0: 543: 57.07		TCPE_YEAST (3-540): 0: 582: 59.89
+	Sp
		140725 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPE_SCHPO (4-541): 0: 598: 68.77
+	Sc
		693035 RPD3_YEAST (3-414): 0: 543: 57.07		TCPH_YEAST (7-540): 0: 542: 30.30
+	Sc
		693017 RPD3_YEAST (3-414): 0: 543: 57.07		TCPG_YEAST (12-541): 0: 540: 31.98
+	Sp
		140519 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPG_SCHPO (12-539): 0: 562: 34.21
+	Sp
		140638 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPH_SCHPO (7-541): 0: 558: 30.00
+	Hs
		177239 HDAC3_HUMAN (1-428): 0: 600: 100.00		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	Hs
		843190 HDAC1_HUMAN (3-385): 0: 588: 62.92		TCPD_HUMAN (36-533): 1.62e-107: 333: 39.80
+	Sc
		693018 RPD3_YEAST (3-414): 0: 543: 57.07		TCPD_YEAST (32-533): 2.31e-99: 312: 36.89
+	Sp
		140614 PHD1_SCHPO (3-407): 0: 519: 56.27		TCPD_SCHPO (32-533): 1.49e-98: 310: 37.45