HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: TCAM1 (Q8IUC6)
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
Gene: TICAM1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.739

The method score is based on:

Property	Details
Experiments	25736436, 27810922, 31511519, 14982987, 14519765, 12471095, 12539043
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002224 - toll-like receptor signaling pathway GO:0005769 - early endosome GO:0010008 - endosome membrane GO:0010628 - positive regulation of gene expression GO:0032722 - positive regulation of chemokine production and 10 others more... GO:0032728 - positive regulation of interferon-beta production GO:0032755 - positive regulation of interleukin-6 production GO:0032760 - positive regulation of tumor necrosis factor production GO:0034138 - toll-like receptor 3 signaling pathway GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043330 - response to exogenous dsRNA GO:0045087 - innate immune response GO:0051607 - defense response to virus GO:0060907 - positive regulation of macrophage cytokine production GO:1900017 - positive regulation of cytokine production involved in inflammatory response
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	904
Hs

1	712

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024