Protein: ZFY16
Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein)

Gene: ZFY16, ZFYVE16
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q7Z3T8

Gene Ontology (top 5):
GO:0005545 - 1-phosphatidylinositol binding
GO:0005547 - phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005769 - early endosome
GO:0005829 - cytosol
GO:0006622 - protein targeting to lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

256477

TOM1
Target of Myb1 membrane trafficking protein

3

17

Small-scale

0.885

High

1141729

EEA1
Early endosome antigen 1

2

20

Small-scale

0.754

High

1277481

ANFY1
Rabankyrin-5

2

9

Small-scale

0.754

High

967820

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

5

11

High-throughput

0.722

High

786697

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

5

11

High-throughput

0.716

High

1277474

PTN23
Tyrosine-protein phosphatase non-receptor type 23

3

7

Small-scale

0.662

High

169617

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

19

Small-scale

0.618

High

296519

STAM2
Signal transducing adapter molecule 2

1

20

Small-scale

0.618

High

336119

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

14

Small-scale

0.618

High

508199

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

11

Small-scale

0.595

High

363495

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

630858

RAB4A
Ras-related protein Rab-4A

2

16

High-throughput

0.584

High

901900

RAB9A
Ras-related protein Rab-9A

2

20

High-throughput

0.584

High

1277476

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.536

High

1277477

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

390639

TFR1
Transferrin receptor protein 1

1

2

High-throughput

0.515

High

1117398

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.515

High

1277488

RNF11
RING finger protein 11

1

5

High-throughput

0.508

High

422439

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

189661

STX7
Syntaxin-7

1

8

High-throughput

0.479

High

226098

STX6
Syntaxin-6

1

6

High-throughput

0.479

High

273549

DJC13
DnaJ homolog subfamily C member 13

1

9

High-throughput

0.479

High

375663

RASK
GTPase KRas

1

17

High-throughput

0.479

High

414101

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

483134

CLCA
Clathrin light chain A

1

5

High-throughput

0.479

High

484170

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.479

High

488507

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

5

Small-scale

0.479

High

540526

LAMP1
Lysosome-associated membrane glycoprotein 1

1

13

High-throughput

0.479

High

541566

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

547636

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

Small-scale

0.479

High

562171

LAMP2
Lysosome-associated membrane glycoprotein 2

1

13

High-throughput

0.479

High

581137

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

593417

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.479

High

601350

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

604061

CXA1
Gap junction alpha-1 protein

1

5

High-throughput

0.479

High

613381

VINC
Vinculin

1

7

High-throughput

0.479

High

631311

RAB5A
Ras-related protein Rab-5A

1

20

High-throughput

0.479

High

695810

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

710854

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.479

High

716578

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

5

Small-scale

0.479

High

771901

CBS
Cystathionine beta-synthase

1

1

Small-scale

0.479

High

787311

ACV1B
Activin receptor type-1B

1

2

Small-scale

0.479

High

787415

TGFR1
TGF-beta receptor type-1

1

2

Small-scale

0.479

High

830976

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

900886

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.479

High

901345

RAB7A
Ras-related protein Rab-7a

1

20

High-throughput

0.479

High

932092

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.479

High

953529

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

968358

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

11

Small-scale

0.479

High

970705

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

976369

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.479

High

978120

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

986526

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

987091

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

5

Small-scale

0.479

High

988480

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

1015554

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

1031434

IFM3
Interferon-induced transmembrane protein 3

1

11

High-throughput

0.479

High

1041143

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1106593

SMAD4
Mothers against decapentaplegic homolog 4

1

12

Small-scale

0.479

High

1107865

SQSTM
Sequestosome-1

1

9

High-throughput

0.479

High

1109845

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1211885

FKB15
FK506-binding protein 15

1

16

Small-scale

0.479

High

1228981

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1233309

LTOR1
Ragulator complex protein LAMTOR1

1

8

High-throughput

0.479

High

1241085

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

7

Small-scale

0.479

High

1254408

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1270873

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

1276185

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1276414

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1277464

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1277466

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

1277467

VP37A
Vacuolar protein sorting-associated protein 37A

1

3

Small-scale

0.479

High

1277469

PDC6I
Programmed cell death 6-interacting protein

1

20

Small-scale

0.479

High

1277470

PF21A
PHD finger protein 21A

1

11

High-throughput

0.479

High

1277471

TS101
Tumor susceptibility gene 101 protein

1

4

Small-scale

0.479

High

1277472

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

1277473

TOLIP
Toll-interacting protein

1

2

High-throughput

0.479

High

1277475

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

1277482

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1277486

MYO6
Unconventional myosin-VI

1

14

High-throughput

0.479

High

1277487

LAMP3
Lysosome-associated membrane glycoprotein 3

1

13

High-throughput

0.479

High

1277480

UBAP1
Ubiquitin-associated protein 1

1

0

Small-scale

0.458

High

1277484

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

179947

BET1
BET1 homolog

1

6

High-throughput

0.437

High

218385

TGON2
Trans-Golgi network integral membrane protein 2

1

11

High-throughput

0.437

High

246714

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

315732

RECQ4
ATP-dependent DNA helicase Q4

1

8

High-throughput

0.437

High

457973

TRY1
Serine protease 1

1

2

Small-scale

0.437

High

556179

CADH1
Cadherin-1

1

4

High-throughput

0.437

High

560435

IFM1
Interferon-induced transmembrane protein 1

1

11

High-throughput

0.437

High

589024

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

641203

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.437

High

642946

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

648568

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.437

High

768520

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

787191

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

Small-scale

0.437

High

931862

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.437

High

945030

RAB25
Ras-related protein Rab-25

1

10

High-throughput

0.437

High

1147359

EPHA7
Ephrin type-A receptor 7

1

19

High-throughput

0.437

High

1251919

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.437

High

1277465

CXD3
Gap junction delta-3 protein

1

5

High-throughput

0.437

High

1277468

SNX29
Sorting nexin-29

1

11

Small-scale

0.437

High

1277478

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.437

High

1277479

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

6

High-throughput

0.437

High

1277483

PEF1
Peflin

1

4

Small-scale

0.437

High

1277485

RCOR1
REST corepressor 1

1

6

High-throughput

0.437

High

1226458

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025