HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: SIG11 (Q96RL6)
Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)
Gene: SIGLEC11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 904 Hs			1 698
+	Hs
		179954 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIG10_HUMAN (28-672): 1.09e-103: 333: 68.43
+	Hs
		177589 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Mm
		1144428 TLR3_MOUSE (8-904): 2.26e-144: 452: 79.93		CD33_MOUSE (14-248): 1.83e-88: 284: 44.26
+	Hs
		179919 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL6_HUMAN (166-458): 2.26e-43: 164: 27.30
+	Mm
		1265316 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		SIGL5_MOUSE (14-675): 1.14e-101: 324: 29.96
+	Mm
		1265317 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIGL5_MOUSE (14-675): 1.14e-101: 324: 29.96
+	Hs
		179970 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Hs
		177607 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Hs
		179969 TLR3_HUMAN (1-904): 2.14e-155: 481: 100.00		SIGL7_HUMAN (160-455): 2.09e-31: 130: 28.79
+	Mm
		1144431 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD33_MOUSE (14-248): 1.83e-88: 284: 44.26
+	Mm
		1144432 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD33_MOUSE (14-248): 1.83e-88: 284: 44.26
+	Mm
		885976 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q3Y597_MOUSE (21-282): 2.22e-79: 257: 37.64
+	Mm
		1113884 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		Q3Y597_MOUSE (21-282): 2.22e-79: 257: 37.64
+	Mm
		1265201 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		SIG12_MOUSE (255-673): 6.47e-58: 205: 20.50
+	Hs
		211423 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL6_HUMAN (166-458): 2.26e-43: 164: 27.30
+	Hs
		1344383 TLR9_HUMAN (1-902): 1.39e-102: 344: 21.01		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Mm
		885977 TLR8_MOUSE (23-901): 7.9e-99: 334: 21.28		Q6PJ50_MOUSE (276-452): 1.74e-38: 150: 37.97
+	Mm
		1162020 TLR4_MOUSE (46-897): 7.68e-95: 319: 19.70		Q6PJ50_MOUSE (276-452): 1.74e-38: 150: 37.97
+	Mm
		722909 TLR5_MOUSE (5-900): 2.42e-95: 320: 19.81		CD22_MOUSE (99-466): 1.88e-31: 133: 21.93
+	Mm
		722910 TLR2_MOUSE (134-899): 4.2e-95: 318: 20.34		CD22_MOUSE (99-466): 1.88e-31: 133: 21.93