Protein: ASGR2
Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (C-type lectin domain family 4 member H2) (Hepatic lectin H2) (HL-2)

Gene: ASGR2
Organism: Homo sapiens
Interactions: 99
UniProt ID: P07307

Gene Ontology (top 5):
GO:0004873 - asialoglycoprotein receptor activity
GO:0005537 - D-mannose binding
GO:0005886 - plasma membrane
GO:0006897 - endocytosis
GO:0006955 - immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

455966

NRG1
Pro-neuregulin-1, membrane-bound isoform

2

7

High-throughput

0.783

High

455981

CL17A
C-type lectin domain family 17, member A

2

16

High-throughput

0.783

High

456007

CLC7A
C-type lectin domain family 7 member A

2

15

High-throughput

0.783

High

456011

LMA2L
VIP36-like protein

4

5

High-throughput

0.691

High

456017

PARVG
Gamma-parvin

3

9

High-throughput

0.667

High

456019

SERC1
Serine incorporator 1

4

0

High-throughput

0.661

High

456010

TTYH3
Protein tweety homolog 3

3

0

High-throughput

0.638

High

455953

SOAT1
Sterol O-acyltransferase 1

4

2

High-throughput

0.630

High

455978

TM214
Transmembrane protein 214

4

1

High-throughput

0.630

High

455946

BIP
Endoplasmic reticulum chaperone BiP

2

7

High-throughput

0.628

High

455994

LMBR1
Limb region 1 protein homolog

2

1

High-throughput

0.611

High

456016

AGRL3
Adhesion G protein-coupled receptor L3

2

7

High-throughput

0.611

High

360241

COX1
Cytochrome c oxidase subunit 1

3

1

High-throughput

0.609

High

455991

MFSD8
Major facilitator superfamily domain-containing protein 8

3

3

High-throughput

0.609

High

139171

UPK2
Uroplakin-2

2

2

High-throughput

0.606

High

328622

VAMP5
Vesicle-associated membrane protein 5

2

1

High-throughput

0.606

High

390420

TFR1
Transferrin receptor protein 1

2

4

High-throughput

0.606

High

455949

CD53
Leukocyte surface antigen CD53

2

9

High-throughput

0.606

High

455950

PPLA
Phospholamban

2

1

High-throughput

0.606

High

455951

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

3

High-throughput

0.606

High

455952

HMOX2
Heme oxygenase 2

2

2

High-throughput

0.606

High

455958

EMP1
Epithelial membrane protein 1

2

2

High-throughput

0.606

High

455964

PMP22
Peripheral myelin protein 22

2

3

High-throughput

0.606

High

455965

ILRL1
Interleukin-1 receptor-like 1

2

11

High-throughput

0.606

High

455977

TSPO2
Translocator protein 2

2

1

High-throughput

0.606

High

455986

MCEM1
Mast cell-expressed membrane protein 1

2

1

High-throughput

0.606

High

456025

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

3

High-throughput

0.606

High

456028

LCAP
Leucyl-cystinyl aminopeptidase

2

1

High-throughput

0.606

High

456029

STX8
Syntaxin-8

2

6

High-throughput

0.606

High

455968

Q08AM2
ADAM33 protein

1

16

High-throughput

0.594

High

455998

ERLEC
Endoplasmic reticulum lectin 1

2

5

Small-scale

0.584

High

220339

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

455962

S35A1
CMP-sialic acid transporter

2

0

High-throughput

0.580

High

455967

PLP2
Proteolipid protein 2

2

0

High-throughput

0.580

High

455975

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.580

High

455987

PAQRA
Monocyte to macrophage differentiation factor 2

2

0

High-throughput

0.580

High

456023

AIG1
Androgen-induced gene 1 protein

2

0

High-throughput

0.580

High

456030

YIPF1
Protein YIPF1

2

0

High-throughput

0.580

High

455999

CERS2
Ceramide synthase 2

2

4

Small-scale

0.565

High

455993

GOGA5
Golgin subfamily A member 5

2

9

High-throughput

0.558

High

456021

ZDH18
Palmitoyltransferase ZDHHC18

2

1

High-throughput

0.558

High

456008

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

12

High-throughput

0.555

High

179800

BET1
BET1 homolog

2

6

High-throughput

0.553

High

455973

ADIPO
Adiponectin

2

8

High-throughput

0.553

High

455988

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

4

High-throughput

0.553

High

455992

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

2

1

High-throughput

0.553

High

456002

SC22A
Vesicle-trafficking protein SEC22a

2

7

High-throughput

0.553

High

456009

SMIM3
Small integral membrane protein 3

2

2

High-throughput

0.553

High

456020

RPRM
Protein reprimo

2

2

High-throughput

0.553

High

456022

TM140
Transmembrane protein 140

2

1

High-throughput

0.553

High

249409

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

2

High-throughput

0.536

High

178891

SCAM2
Secretory carrier-associated membrane protein 2

2

1

High-throughput

0.521

High

455979

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

5

High-throughput

0.489

High

455947

CO6A1

1

0

High-throughput

0.481

High

455955

SYUA
Alpha-synuclein

1

4

High-throughput

0.481

High

455956

GLP1R
Glucagon-like peptide 1 receptor

1

4

Small-scale

0.481

High

222643

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

455985

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

5

Small-scale

0.479

High

455995

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

4

Small-scale

0.479

High

456005

DERL1
Derlin-1

1

1

Small-scale

0.479

High

456018

FBX6
F-box only protein 6

1

4

Small-scale

0.479

High

376669

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.445

High

455959

CD81
CD81 antigen

1

8

High-throughput

0.445

High

455971

LAMC2
Laminin subunit gamma-2

1

10

High-throughput

0.445

High

456032

NPTN
Neuroplastin

1

9

High-throughput

0.445

High

455983

MROH5
Maestro heat-like repeat family member 5

1

6

High-throughput

0.439

High

456004

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

1

Small-scale

0.439

High

455948

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

12

High-throughput

0.437

High

455963

EREP3
Protein ENTREP3

1

3

High-throughput

0.437

High

455970

OS9
Protein OS-9

1

5

Small-scale

0.437

High

455976

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.437

High

456000

P121A
Nuclear envelope pore membrane protein POM 121

1

4

High-throughput

0.437

High

456026

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

456027

EGFL7
Epidermal growth factor-like protein 7

1

12

High-throughput

0.437

High

318943

MICA2
[F-actin]-monooxygenase MICAL2

1

10

High-throughput

0.407

High

456006

C1QT2
Complement C1q tumor necrosis factor-related protein 2

1

8

High-throughput

0.407

High

455982

TMPPE
Transmembrane protein with metallophosphoesterase domain

4

0

High-throughput

0.361

High

456003

JMJD8
JmjC domain-containing protein 8

4

0

High-throughput

0.360

High

456015

FKRP
Ribitol 5-phosphate transferase FKRP

4

0

High-throughput

0.360

High

455954

TIMP3
Metalloproteinase inhibitor 3

3

0

High-throughput

0.347

High

455961

RL23
Large ribosomal subunit protein uL14

3

0

High-throughput

0.347

High

455990

S38A9
Neutral amino acid transporter 9

3

0

High-throughput

0.347

High

455984

FA2H
Fatty acid 2-hydroxylase

2

0

High-throughput

0.316

High

455989

TM86B
Lysoplasmalogenase TMEM86B

2

0

High-throughput

0.316

High

455996

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.316

High

456013

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

456024

ORML1
ORM1-like protein 1

2

0

High-throughput

0.316

High

456031

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.316

High

359572

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.251

Low

455972

HES1
Transcription factor HES-1

1

0

High-throughput

0.251

Low

455957

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.249

Low

455969

SBP1
Methanethiol oxidase

1

0

High-throughput

0.249

Low

455974

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

0

High-throughput

0.249

Low

455980

HACD2
Very-long-chain

1

0

High-throughput

0.249

Low

455997

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

0

High-throughput

0.249

Low

456001

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.249

Low

455960

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.232

Low

456012

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.232

Low

456014

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025