HitPredict

Interactor 1: TLR3 (O15455)
Toll-like receptor 3 (CD antigen CD283)
Gene: TLR3

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.687

The method score is based on:

Property Details
Experiments 12609980, 27810922, 21911421, 16115877
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007250 - activation of NF-kappaB-inducing kinase activity
GO:0010008 - endosome membrane
GO:0032735 - positive regulation of interleukin-12 production
and 5 others

more...
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 904
Hs

1 522
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024