HitPredict

Interactor 1: CCL16 (O15467)
C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)
Gene: CCL16

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11470772
Identification Methods	fluorescence technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0007186 - G protein-coupled receptor signaling pathway GO:0007267 - cell-cell signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 120 Hs			1 352
+	Hs
		180158 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		849654 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		180160 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR2_HUMAN (2-331): 3.91e-79: 248: 70.91
+	Hs
		561733 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		526565 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR5_HUMAN (1-352): 5.2e-84: 260: 100.00
+	Hs
		1305163 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR4_HUMAN (2-340): 3.18e-82: 255: 30.35
+	Hs
		561728 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		526560 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR1_HUMAN (12-352): 6.79e-81: 252: 56.73
+	Hs
		783833 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR2_HUMAN (2-331): 3.91e-79: 248: 70.91
+	Mm
		500591 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR3_MOUSE (6-352): 1.47e-80: 251: 55.46
+	Hs
		180159 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CXCR5_HUMAN (7-346): 8.85e-70: 224: 26.74
+	Hs
		180162 CCL16_HUMAN (1-120): 3.49e-39: 129: 100.00		CCR8_HUMAN (1-348): 3.88e-69: 222: 40.79
+	Mm
		500590 CCL3_MOUSE (1-95): 9.34e-34: 114: 37.50		CCR1_MOUSE (4-352): 2.53e-73: 232: 54.57
+	Hs
		526561 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CXCR5_HUMAN (7-346): 8.85e-70: 224: 26.74
+	Hs
		849619 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		561732 CL3L1_HUMAN (1-95): 2.37e-34: 115: 34.38		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		526564 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		CCR3_HUMAN (1-352): 2.82e-68: 219: 49.86
+	Hs
		134400 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		134356 CCL4_HUMAN (1-94): 7.42e-34: 114: 38.95		ACKR2_HUMAN (20-312): 2.55e-52: 179: 37.97
+	Hs
		830629 CCL13_HUMAN (1-99): 3.28e-35: 118: 31.00		CXCR3_HUMAN (16-308): 2.75e-47: 165: 36.49